Subjects/description | Genetic marker | Result* | Phenotype | Ref |
---|---|---|---|---|
   A. Sib-pair study | ||||
Non-diabetic Pima Indians | [4] | |||
 | MNS red cell antigen | + | maximal insulin-stimulated glucose uptake |  |
 |  | + | insulin action index |  |
 |  | - | fasting insulin |  |
Non-diabetic Pima Indians | [5] | |||
 | ANX5 | + | maximal insulin-stimulated glucose uptake |  |
 | FABP2 | + | maximal insulin-stimulated glucose uptake |  |
 |  | + | fasting insulin |  |
Non-diabetic Mexican Americans | [15] | |||
 | FABP2 | + | 2-h post challenge insulin levels |  |
Pondicherian Tamil Indians | [16] | |||
 | A54T | - | diabetes, body mass index, |  |
 |  | - | waist/hip ratio, insulinemia |  |
 |  | - | glycemia, triglyceride, total cholesterol |  |
French families with morbid obesity | [17] | |||
 | FABP2 | - | body mass index, adult life body with gain |  |
 |  |  | fasting leptin, insulin, glycerol, free fatty acid |  |
   B. Linkage study | ||||
Mexican American diabetic pedigrees | [18] | |||
 | FABP2 | - | diabetes |  |
French diabetic pedigrees | [19] | |||
 | FABP2 | - | diabetes |  |
Pedigrees with lipodystrophic diabetes | [20] | |||
 | FABP2 | - | lipodystrophic diabetes |  |
French families with morbid obesity | [17] | |||
 | FABP2 | - | obesity |  |
   C. Population association study | ||||
UK, Finnish and Welsh population | [21] | |||
 | FABP2 | - | diabetes/impaired glucose tolerance |  |
Pima Indian population | [9] | |||
 | A54T | - | diabetes |  |
Japanese population | [22] | |||
 | FABP2 | - | diabetes/impaired glucose tolerance |  |
Aboriginal Canadians population | [28] | |||
 | A54T | - | diabetes |  |
Canadian Inuit population | [26] | |||
 | A54T | - | coronary artery disease |  |
Diabetic and nondiabetic Finnish population | [27] | |||
 | A54T | - | coronary artery disease |  |
Japanese population | [23] | |||
 | A54T | - | diabetes |  |
Japanese population | [24] | |||
 | A54T | - | diabetes, obesity, hypertension |  |
African Americans population | [25] | |||
 | A54T | - | diabetes |  |
   D. Quantitative association study | ||||
Non-diabetic Pima Indians | [9] | |||
 | A54T | + | fasting insulin, fasting fat oxidation |  |
 |  | + | glucose uptake |  |
Aboriginal Canadians | [13] | |||
 | A54T | + | body mass index, percent body fat |  |
 |  | + | fasting plasma triglyceride |  |
Finnish non-diabetic and diabetic subjects | [31] | |||
 | A54T | - | insulin sensitivity |  |
Obese Finnish subjects | [32] | |||
 | A54T | - | fatty acid composition |  |
Japanese subjects without fasting hyperglycemia | [14] | |||
 | A54T | + | 2-hour post challenge insulin, |  |
 |  | + | intraabdominal fat |  |
Aboriginal Canadians | [36] | |||
 | A54T | + | plasma triglyceride |  |
Finnish patients with familial combined hyperlipidemia | [29] | |||
 | A54T | + | lipid oxidation rate, HDL triglycerides, |  |
 |  | + | LDL triglyceride |  |
 |  | - | insulin sensitivity |  |
Obese Finnish subjects | [33] | |||
 | A54T | - | fasting insulin, glucose, lipid |  |
 |  | - | lipoprotein, basal metabolic rate, |  |
 |  | - | glucose and lipid oxidation |  |
Japanese population | [23] | |||
 | A54T | - | insulin sensitivity |  |
Japanese population | [24] | |||
 | A54T | - | dyslipidemia, hyperuricemia |  |
 |  | - | hyperinsulinemia |  |
Guadeloupe Indian population | [30] | |||
 | A54T | + | triglyceride |  |
American Caucasian population | ** | |||
 | A54T | + | insulin sensitivity (%S) |  |
   E. Interventional study | ||||
Response to dietary fiber in Canadian subjects | [36] | |||
 | A54T | + | greater decreases in total |  |
 |  | + | LDL cholesterol and Apo-B |  |
Postprandial lipemic response in normotriglyceridemic subjects | [35] | |||
 | A54T | + | greater increases in chylomicron and VLDL triglycerides! |  |