Background | Total | Pupil/iris | Cornea | Cataract | Vitreous vessels | Optic nerve |
|---|
C57BL/6J | 31/31 | 30/31 | 13/31 | 7/31 | 23/31 | 18/30* |
CAST/Ei | 1/7 | 0/7 | 0/7 | 1/7 | 0/7 | 0/7 |
129/SvEvT ac | 1/12 | 1/12 | 0/12 | 0/12 | 1/12 | 0/12 |
BALB/cJ | 1/15 | 0/15 | 0/15 | 0/15 | 1/15 | 0/15 |
C3H.BLia | 6/13 | 5/13 | 3/13 | 0/13 | 1/13 | 0/13 |
- *Due to corneal opacities and vitreous vessels, the optic nerves were not clearly viewed in all eyes but considering viewable nerves 12 mice appeared normal. In all cases, the numerator indicates the number of mice affected and the denominator indicates the number analyzed. On C57BL/6J, the eyes of 21 mice were bilaterally affected and 10 unilaterally affected. On all other backgrounds the mice were unilaterally affected. For C57BL/6J, another 100 mice were analyzed. Ninety-five of these were affected but the incidence of specific features was not recorded. Pupil and iris abnormalities included irregularly shaped pupils and iris attachments to the cornea. Corneal lesions included scarring and vascularization. Vitreous vessels indicates the abnormal persistence of these vessels. Aberrant optic nerves typically appeared very cupped and colobomatous. More details of specific phenotypes are provided in the text. C57BL/6J were backcross generation N11 or greater, other strains were N2 or greater. For all backgrounds, wild type controls were analyzed but are not included in the table as none were affected.
