TY - JOUR AU - Calin, George AU - Ranzani, Guglielmina N. AU - Amadori, Dino AU - Herlea, Vlad AU - Matei, Irina AU - Barbanti-Brodano, Giuseppe AU - Negrini, Massimo PY - 2001 DA - 2001/08/14 TI - Somatic frameshift mutations in the Bloom syndrome BLM gene are frequent in sporadic gastric carcinomas with microsatellite mutator phenotype JO - BMC Genetics SP - 14 VL - 2 IS - 1 AB - Genomic instability has been reported at microsatellite tracts in few coding sequences. We have shown that the Bloom syndrome BLM gene may be a target of microsatelliteinstability (MSI) in a short poly-adenine repeat located in its coding region. To further characterize the involvement of BLM in tumorigenesis, we have investigated mutations in nine genes containing coding microsatellites in microsatellite mutator phenotype (MMP) positive and negative gastric carcinomas (GCs). SN - 1471-2156 UR - https://doi.org/10.1186/1471-2156-2-14 DO - 10.1186/1471-2156-2-14 ID - Calin2001 ER -