Anterior synechiae and elevated IOP in AKXD28. (a) Young mice have normal, unobstructed iridocorneal angles. The angle has a well developed trabecular meshwork (TM, arrowhead) and open Schlemm's Canal (SC). (b) A large anterior synechia (arrow) has occluded the TM and SC in a 14 month old mouse. As shown in c (and see Table 1), the formation of synechiae is followed by IOP elevation. Two standard deviations (2 SD) above the mean IOP for 7-10 month mice is indicated by the dashed line (females) and a full line (males). Ciliary body atrophy occurs in some mice and its incidence increases with age. Although histologic analysis and IOP measurement were not performed on the same eyes, it seems likely that ciliary body atrophy explains the drop in female IOP at 19 to 21 months. Original magnifications 400X.