Table 1 Genes differentially expressed in ISIAH and WAG kidney and localized in QTL for absolute and relative kidney weight in 6-month old F2 (ISIAH × WAG) males
QTL | Genes differentially expressed in ISIAH and WAG kidney∆ | ||||||
|---|---|---|---|---|---|---|---|
Chr. | Peak marker (Mb) | Confidence interval, * Mb | Ratio ISIAH/ WAG | Acc.# | Symbol | Mb | Definition |
kidney_weight | |||||||
4 | D4Rat68 (233.3) | 204-242 | 0.37 0.56 (p<0.05) 0.36 | NM_001009661.1 NM_017336.1 NM_017336.1 | Wbp11 Ptpro Ptpro | 234.4 235.5 235.5 | WW domain binding protein 11 Protein tyrosine phosphatase, receptor type, O Protein tyrosine phosphatase, receptor type, O |
6 | D6Rat143 (48.1) | 42-62 | 0.56 0.38 | XM_576132.1 XM_001074910.1 | Txndc7 Oact2 | 52.3 60.9 | Thioredoxin domain containing 7 O-acyltransferase (membrane bound) domain containing 2 |
10 | D10Rat43 (22.3) | 10-58 | 1.69 0.42 0.38 | XM_220308.4 NM_172335.2 NM_172335.2 | Wwc1 Gm2a Gm2a | 20.5 40.3 40.3 | WW and C2 domain containing 1 GM2 ganglioside activator GM2 ganglioside activator |
15 | D15Rat80 (30.3) | 18-50 | 0.28 1.66 | NM_013219.1 XM_001054512.1 | Cadps RGD1308430 | 19.3 37.2 | Ca++-dependent secretion activator Similar to 1700123O20Rik protein |
17 | D17Rat107 (11.8) | 0-24 | 1.84 0.51 0.35 0.08 6.54 5.06 | XM_001061265.1 NM_181626.3 NM_181626.3 XM_346945.2 NM_001014007.1 NM_001014007.1 | LOC682869 Isca1 Isca1 RGD1564391 LOC306766 LOC306766 | 5.1 7.5 7.5 7.8 12.7 12.7 | similar to Golgi phosphoprotein 2 (Golgi membrane protein GP73), transcript variant 2 Iron-sulfur cluster assembly 1 homolog (S. cerevisiae) Iron-sulfur cluster assembly 1 homolog (S. cerevisiae) RGD1564391 (predicted) Hypothetical LOC306766 Hypothetical LOC306766 |
ln_relative_kidney_ weight | |||||||
3 | D3Rat56-D3Rat130 (2.6-55.2) | 0-62 | 0.37 0.11 | NM_001004280.1 NM_001004280.1 | Mmadhc Mmadhc | 40.9 40.9 | methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria |
6 | D6Rat143 (48.1) | 42-62 | 0.56 0.38 | XM_576132.1 XM_001074910.1 | Txndc7 Oact2 | 52.3 60.9 | Thioredoxin domain containing 7 O-acyltransferase (membrane bound) domain containing 2 |
7 | D7Rat51-D7Rat165 (54.6-73.5) | 44-84 | 0.57 | XM_235156.4 | Ptprb | 59.4 | protein tyrosine phosphatase, receptor type, B (predicted) |