TY - JOUR AU - Fu, Guifang AU - Saunders, Garrett AU - Stevens, John PY - 2014 DA - 2014/06/20 TI - Holm multiple correction for large-scale gene-shape association mapping JO - BMC Genetics SP - S5 VL - 15 IS - 1 AB - Linkage Disequilibrium (LD) is a powerful approach for the identification and characterization of morphological shape, which usually involves multiple genetic markers. However, multiple testing corrections substantially reduce the power of the associated tests. In addition, the principle component analysis (PCA), used to quantify the shape variations into several principal phenotypes, further increases the number of tests. As a result, a powerful multiple testing correction for simultaneous large-scale gene-shape association tests is an essential part of determining statistical significance. Bonferroni adjustments and permutation tests are the most popular approaches to correcting for multiple tests within LD based Quantitative Trait Loci (QTL) models. However, permutations are extremely computationally expensive and may mislead in the presence of family structure. The Bonferroni correction, though simple and fast, is conservative and has low power for large-scale testing. SN - 1471-2156 UR - https://doi.org/10.1186/1471-2156-15-S1-S5 DO - 10.1186/1471-2156-15-S1-S5 ID - Fu2014 ER -