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Figure 2 | BMC Genetics

Figure 2

From: SPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegans

Figure 2

spe-8 exonic structure and sequence alignment of its protein product. The exonic structure shown in A is supported by numerous EST sequences curated by WormBase (http://www.wormbase.org). The locations of mutations in the spe-8 gene were mapped onto (A) the exon structure and (B) a multiple alignment of SPE-8 from C. elegans and the top BLAST matches from other nematodes. The nucleotide alterations to codons are shown in A, and the amino acid changes are shown in B. Included in the alignment is the human c-Abl Tyrosine Kinase from structural analysis of the protein (Figure 3). The location of the SH2 domain is indicated by the red line, and the kinase domain is indicated by the blue line.

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