Figure 5

The association of CNP haplotypes with uric acid levels is independent of genome-wide significant SNPs. Genotypes at rs7675964 and rs6449213 were phased with CNP-9 Mb and CNP-10 Mb. Subjects were stratified into three allelic haplotypes (column labels) for which there was variation in the CNP haplotypes (y-axis labels). The pair of CNP haplotypes given by ${}_{\text{H2:}--0--1--}^{\text{H1:}--0--1--}$ is the reference group for each regression. Likelihood ratio tests for the CNP haplotypes are statistically significant for women with allelic haplotypes ${}_{\text{H2:}--a--a--}^{\text{H1:}--a--a--}$ (${\chi }_{4\text{df}}^2=14.3,p=6.3\times 10^{-03}$) and marginally significant for both men and women with allelic haplotypes ${}_{\text{H2:}--a--a--}^{\text{H1:}--b--b--}$ (${\chi }_{4\text{df}}^2=9.05,p=0.0599$). CNP haplotypes are not associated with uric acid concentrations among ${}_{\text{H2:}--a--a--}^{\text{H1:}--b--a--}$ subjects (${\chi }_{2\text{df}}^2=2.06,p=0.357$), though the sample size for this cohort is small and the effect size among the 66 women is comparable to the effect size in the much larger ${}_{\text{H2:}--a--a--}^{\text{H1:}--b--b--}$ and ${}_{\text{H2:}--a--a--}^{\text{H1:}--a--a--}$ subgroups.