Table 3 Power comparisons for different approaches at the 0.05 level of significance for 3 different simulation scenarios using genotypes coded as additive, dominant, and recessive, respectively, for 40% and 20% MAFs
From: Calculation of exact p-values when SNPs are tested using multiple genetic models
| Â | Â | Genotype model | ||
|---|---|---|---|---|
MAF | Method | Additive model | Dominant model | Recessive model |
Odds ratio = 1.2 | Odds ratio = 1.3 | Odds ratio = 1.3 | ||
| Â | Additive Only | 0.816 | 0.660 | 0.410 |
| Â | Dominant Only | 0.676 | 0.803 | 0.116 |
40% | Recessive Only | 0.588 | 0.158 | 0.589 |
| Â | Bonferroni | 0.721 | 0.671 | 0.452 |
| Â | Exact p-value | 0.743 | 0.726 | 0.517 |
| Â | Additive Only | 0.656 | 0.774 | 0.116 |
| Â | Dominant Only | 0.603 | 0.823 | 0.061 |
20% | Recessive Only | 0.306 | 0.102 | 0.249 |
| Â | Bonferroni | 0.556 | 0.715 | 0.168 |
| Â | Exact p-value | 0.584 | 0.782 | 0.197 |