Performance of HLA allele prediction methods in African Americans for class II genes HLA-DRB1, −DQB1, and –DPB1

Table 2 HLA allele imputation accuracy in ACCESS African Americans for HLA class II genes HLA-DRB1 , − DQB1 , and –DPB1

Abbreviations: PP denotes, posterior prediction probability; N, count; Accuracy, imputation accuracy.
*HLA*IMP:02 is described in Dilthey et al. 2013. In this version of the software, reference data for HLA-DPB1 was not available for the African ancestry reference panel.
†HIBAG African ancestry model (published online 8/10/2012).
‡The models trained on the subset of ACCESS African Americans with training samples selected at random (from a total of 325) to match the number of subjects used to construct the published HIBAG African ancestry models: HLA-DRB1 (n = 161), HLA-DQB1 (n = 137), and HLA-DPB1 (n = 75).
§One- and two-field estimates will be very similar for HLA-DPB1 as the first field uniquely identifies the two-field alleles, with the exceptions of *02:01 and *0202, and *04:01 and *04:02.

ISSN: 2730-6844