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Table 1 Comparison of HLA allele imputation accuracy in ACCESS European Americans for HLA class II genes HLA-DRB1 , − DQB1 , and −DPB1 between HLA*IMP:02* and HIBAG †

From: Performance of HLA allele prediction methods in African Americans for class II genes HLA-DRB1, −DQB1, and –DPB1

  

HLA*IMP:02*

HIBAG†

  

All

All

PP > 0.5

Gene

Allele field

N

Accuracy

Accuracy

N

Call rate

Accuracy

DRB1

One

480

98.5

98.9

440

91.7

99.8

 

Two

480

90.4

92.4

440

91.7

94.4

DQB1

One

480

99.5

99.7

476

99.2

99.7

 

Two

480

97.1

97.0

476

99.2

97.2

DPB1‡

One

480

83.0

93.2

469

97.7

93.6

 

Two

480

82.1

92.7

469

97.7

93.2

  1. Abbreviations: PP denotes, posterior prediction probability; N, count; Accuracy, imputation accuracy.
  2. *HLA*IMP:02 is described in Dilthey et al. 2013.
  3. †HIBAG European ancestry model (published online 8/10/2012).
  4. ‡One- and two-field estimates will be very similar for HLA-DPB1 as the first field uniquely identifies the two-field alleles, with the exceptions of *02:01 and *0202, and *04:01 and *04:02.
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BMC Genomic Data

ISSN: 2730-6844

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