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Table 2 Haplotype diversity analysis of the 32 ADME core genes

From: Increased genetic diversity of ADME genes in African Americans compared with their putative ancestral source populations and implications for Pharmacogenomics

Gene

Hd ASW

Hd CEU

Hd YRI

P value of 10000 times resampling

    

ASW_CEU

ASW_YRI

CEU_YRI

ABCB1

0.6853

0.7284

0.6655

0.3221

0.6599

0.1000

ABCC2

0.6151

0.6966

0.6652

0.0238

0.2121

0.2892

ABCG2

0.9678

0.8872

0.9414

0.0000

0.0400

0.0001

CYP1A1

0.4050

0.2184

0.3655

0.0200

0.4900

0.0062

CYP1A2

0.7904

0.4904

0.6999

0.0000

0.0022

0.0000

CYP2A6

0.3781

0.1962

0.4553

0.0200

0.2600

0.0000

CYP2B6

0.8594

0.7722

0.8208

0.0021

0.2014

0.1000

CYP2C19

0.8328

0.6718

0.8701

0.0000

0.1229

0.0000

CYP2C8

0.3333

0.2178

0.3205

0.0800

0.9400

0.0800

CYP2C9

0.2800

0.1009

0.3358

0.0028

0.5000

0.0000

CYP2D6

0.7261

0.7436

0.7233

0.5936

0.9600

0.4799

CYP2E1

0.7009

0.4614

0.7062

0.0000

0.8974

0.0000

CYP3A4

0.4552

0.0578

0.3594

0.0000

0.0285

0.0000

CYP3A5

0.5461

0.1125

0.4932

0.0000

0.2577

0.0000

DPYD

0.4975

0.2847

0.4901

0.0000

0.7000

0.0000

GSTP1

0.5182

0.5415

0.4742

0.4746

0.0912

0.0600

GSTT1

0.4054

0.2178

0.1662

0.0004

0.0000

0.3400

NAT1

0.5198

0.4005

0.5109

0.0035

0.8000

0.0060

NAT2

0.8245

0.6897

0.8673

0.0000

0.0283

0.0000

SLC22A1

0.6034

0.7277

0.5445

0.0040

0.2492

0.0000

SLC22A2

0.2536

0.1619

0.2691

0.1800

0.8000

0.0392

SLC22A6

0.1236

0.0000

0.1278

0.0015

0.9338

0.0001

SLCO1B1

0.7177

0.6446

0.6918

0.1400

0.5753

0.3198

SLCO1B3

0.8954

0.6618

0.9010

0.0000

0.6520

0.0000

SULT1A1

0.1378

0.0685

0.1847

0.1505

0.5000

0.0096

TPMT

0.6124

0.5236

0.5688

0.0375

0.6000

0.2234

UGT1A1

0.7508

0.5671

0.6923

0.0000

0.0049

0.0001

UGT2B7

0.7506

0.6741

0.7337

0.0470

0.8000

0.1000

  1. The haplotype diversity values of 32 ADME core genes in three populations, and the significances of haplotype diversity between each two populations were calculated by 10000 times resampling. More detailed haplotype information of each gene can be found in Additional file 10: Table S3.