Table 4 Mean longevity of adult flies with the misexpression of reduced-lifespan genes in specific adult tissues
Reduced-lifespan gene | GS line. no. | GAL4 driver line | |||||||
|---|---|---|---|---|---|---|---|---|---|
P{GawB}l(3)31-1 31–1 | 48Y-GAL4 | 24B-GAL4 | NP5021 | byn-GAL4 | drm-GAL4 | Cg-GAL4 | P{GawB}5108 | ||
Transportin | 11030 | 33.4 | 33.5 | 32.7 | 15.6 | 39.8 | 33.5 | 25.6 | 33.0 |
Dream | 16231 | 29.1 | 34.7 | 3.0 | 4.6 | 21.8 | 25.2 | 30.9 | (30.0) |
CG10277 | 11124 | 35.4 | 32.5 | 23.4 | 7.6 | 25.1 | 27.9 | 27.9 | 32.1 |
Hepatocyte nuclear factor 4 | 10535 | 37.8 | 29.1 | 27.7 | 13.8 | 25.3 | 30.2 | 31.6 | 35.5 |
Calpain-A | 9176 | 30.0 | (37.8) | 23.5 | 17.8 | (19.5) | 21.3 | 23.5 | 29.4 |
Transfer RNA:ile:49Fb | 14941 | 33.3 | (19.2) | 33.7 | 4.1 | 28.8 | 31.2 | 29.0 | 36.8 |
Combgap | 11121 | 27.6 | 28.8 | 5.5 | 20.1 | 7.8 | 20.5 | 30.7 | (28.8) |
trpγ | 16894 | 33.2 | 31.0 | 31.0 | 19.2 | 30.8 | 27.0 | 35.3 | (31.2) |
Apontic | 15217 | 9.4 | 27.9 | 36.3 | 7.8 | 34.4 | 29.1 | 31.7 | 25.5 |
Cadmus | 14710 | 33.3 | 35.3 | 38.2 | 26.7 | 36.9 | 21.0 | 26.6 | 34.3 |
PolyA-binding protein | 15168 | 33.0 | 32.1 | 9.3 | 5.3 | 23.2 | 29.8 | 26.3 | 35.1 |
Embryonic lethal abnormal vision | 5211 | 27.7 | 31.1 | 6.0 | 30.0 | 12.2 | 33.0 | 26.6 | 31.5 |
CG3363 | 11052 | 20.7 | 18.5 | 8.8 | 11.6 | 22.4 | 19.5 | 21.0 | 33.9 |
Stonewall | 8015 | 24.8 | 33.4 | 12.6 | 10.2 | 18.7 | 32.6 | 17.1 | 36.0 |
Degringolade | 15270 | 22.6 | 33.3 | 20.1 | 9.2 | 17.0 | 11.6 | 29.7 | 36.5 |
Atlastin | 17467 | 8.5 | 35.1 | 27.3 | 16.2 | 17.3 | 31.7 | 30.2 | 42.2 |
Chromator | 16669 | 25.5 | 17.1 | 5.3 | 13.1 | 9.6 | 9.6 | 14.6 | (27.0) |
Slipper | 7470 | 13.1 | 14.8 | 7.3 | 26.8 | 21.9 | 25.5 | 8.1 | 26.7 |
Polo | 16634 | 30.9 | 13.6 | 29.6 | 24.3 | 24.9 | 35.1 | 28.8 | 35.6 |
Without children | 10711 | 27.3 | 38.1 | 16.3 | 8.1 | 22.3 | 26.3 | 16.7 | 29.0 |
Heterogeneous nuclear ribonucleoprotein at 27C | 13072 | 18.5 | 13.8 | 6.0 | 13.8 | 5.1 | 15.6 | 25.8 | 33.5 |
High mobility group protein D | 10665 | 10.4 | 6.9 | 3.0 | 6.0 | 5.4 | 21.6 | 23.4 | 29.2 |
Fmr1 | 11947 | 30.0 | 21.4 | 5.8 | 14.8 | 15.0 | 23.7 | 14.5 | (36.6) |
Peroxin 16 | 12435 | 34.3 | 32.0 | 24.0 | 12.8 | 32.4 | 18.6 | 31.7 | (21.6) |
Pipsqueak | 12449 | 27.3 | 30.4 | 7.7 | 6.0 | 25.4 | 30.5 | 29.4 | 29.0 |
CG8290 | 12665 | 32.1 | 21.7 | 19.2 | 26.4 | 16.4 | 33.6 | 32.4 | 37.0 |
Vacuolar H + ATPase subunit 100-2 | 10911 | 35.8 | (35.4) | 34.2 | 26.4 | 24.4 | 29.1 | 35.3 | (37.2) |
CG10321 | 10668 | 24.6 | 35.0 | 12.0 | 10.5 | 13.4 | 35.3 | 19.3 | 32.8 |
Roadkill | 15233 | 32.9 | 38.5 | 27.9 | 31.1 | 34.1 | 32.8 | 31.4 | (35.3) |
Lamin | 16890 | 21.5 | 22.5 | 21.6 | 6.0 | 12.2 | 17.8 | 10.9 | 23.9 |
Elfless | 15946 | 30.6 | 28.4 | 22.8 | 20.6 | 20.6 | 31.4 | 29.9 | 34.4 |
CG16779 | 9601 | 26.9 | 34.5 | 11.7 | 16.5 | 31.2 | 34.5 | 18.0 | 45.0 |
Elongation factor Tu mitochondrial | 11862 | 29.0 | 28.3 | 23.3 | 22.8 | 31.5 | 15.5 | 31.3 | (27.6) |
CG11819 | 5065 | 31.1 | 35.0 | 31.5 | 7.5 | 28.1 | 30.2 | 32.1 | 34.7 |
Autophagy-specific gene 1 | 15847 | 29.5 | 34.2 | 32.6 | 14.7 | 28.1 | 27.2 | 31.7 | 37.8 |
CG8032 | 5196 | 38.4 | 28.4 | 33.9 | 12.6 | 30.0 | 35.1 | 28.8 | 32.0 |
N-methyl-D-aspartate receptor-associated protein | 16440 | 27.6 | 5.5 | 15.4 | 15.8 | 20.6 | 16.7 | 23.9 | 31.5 |
Src oncogene at 42A | 11049 | 21.6 | 21.9 | 17.1 | 9.8 | 19.2 | 24.6 | 16.1 | 33.0 |
CG30482 | 9799 | 32.8 | 37.4 | 30.8 | 31.1 | 29.3 | 9.9 | 13.8 | 35.8 |
Canton-S (control) | 37.6 | 32.9 | 34.9 | 31.5 | 31.8 | 35.7 | 28.4 | 34.4 | |