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Table 4 Mean longevity of adult flies with the misexpression of reduced-lifespan genes in specific adult tissues

From: A gain-of-function screen to identify genes that reduce lifespan in the adult of Drosophila melanogaster

Reduced-lifespan gene GS line. no. GAL4 driver line
P{GawB}l(3)31-1 31–1 48Y-GAL4 24B-GAL4 NP5021 byn-GAL4 drm-GAL4 Cg-GAL4 P{GawB}5108
Transportin 11030 33.4 33.5 32.7 15.6 39.8 33.5 25.6 33.0
Dream 16231 29.1 34.7 3.0 4.6 21.8 25.2 30.9 (30.0)
CG10277 11124 35.4 32.5 23.4 7.6 25.1 27.9 27.9 32.1
Hepatocyte nuclear factor 4 10535 37.8 29.1 27.7 13.8 25.3 30.2 31.6 35.5
Calpain-A 9176 30.0 (37.8) 23.5 17.8 (19.5) 21.3 23.5 29.4
Transfer RNA:ile:49Fb 14941 33.3 (19.2) 33.7 4.1 28.8 31.2 29.0 36.8
Combgap 11121 27.6 28.8 5.5 20.1 7.8 20.5 30.7 (28.8)
trpγ 16894 33.2 31.0 31.0 19.2 30.8 27.0 35.3 (31.2)
Apontic 15217 9.4 27.9 36.3 7.8 34.4 29.1 31.7 25.5
Cadmus 14710 33.3 35.3 38.2 26.7 36.9 21.0 26.6 34.3
PolyA-binding protein 15168 33.0 32.1 9.3 5.3 23.2 29.8 26.3 35.1
Embryonic lethal abnormal vision 5211 27.7 31.1 6.0 30.0 12.2 33.0 26.6 31.5
CG3363 11052 20.7 18.5 8.8 11.6 22.4 19.5 21.0 33.9
Stonewall 8015 24.8 33.4 12.6 10.2 18.7 32.6 17.1 36.0
Degringolade 15270 22.6 33.3 20.1 9.2 17.0 11.6 29.7 36.5
Atlastin 17467 8.5 35.1 27.3 16.2 17.3 31.7 30.2 42.2
Chromator 16669 25.5 17.1 5.3 13.1 9.6 9.6 14.6 (27.0)
Slipper 7470 13.1 14.8 7.3 26.8 21.9 25.5 8.1 26.7
Polo 16634 30.9 13.6 29.6 24.3 24.9 35.1 28.8 35.6
Without children 10711 27.3 38.1 16.3 8.1 22.3 26.3 16.7 29.0
Heterogeneous nuclear ribonucleoprotein at 27C 13072 18.5 13.8 6.0 13.8 5.1 15.6 25.8 33.5
High mobility group protein D 10665 10.4 6.9 3.0 6.0 5.4 21.6 23.4 29.2
Fmr1 11947 30.0 21.4 5.8 14.8 15.0 23.7 14.5 (36.6)
Peroxin 16 12435 34.3 32.0 24.0 12.8 32.4 18.6 31.7 (21.6)
Pipsqueak 12449 27.3 30.4 7.7 6.0 25.4 30.5 29.4 29.0
CG8290 12665 32.1 21.7 19.2 26.4 16.4 33.6 32.4 37.0
Vacuolar H + ATPase subunit 100-2 10911 35.8 (35.4) 34.2 26.4 24.4 29.1 35.3 (37.2)
CG10321 10668 24.6 35.0 12.0 10.5 13.4 35.3 19.3 32.8
Roadkill 15233 32.9 38.5 27.9 31.1 34.1 32.8 31.4 (35.3)
Lamin 16890 21.5 22.5 21.6 6.0 12.2 17.8 10.9 23.9
Elfless 15946 30.6 28.4 22.8 20.6 20.6 31.4 29.9 34.4
CG16779 9601 26.9 34.5 11.7 16.5 31.2 34.5 18.0 45.0
Elongation factor Tu mitochondrial 11862 29.0 28.3 23.3 22.8 31.5 15.5 31.3 (27.6)
CG11819 5065 31.1 35.0 31.5 7.5 28.1 30.2 32.1 34.7
Autophagy-specific gene 1 15847 29.5 34.2 32.6 14.7 28.1 27.2 31.7 37.8
CG8032 5196 38.4 28.4 33.9 12.6 30.0 35.1 28.8 32.0
N-methyl-D-aspartate receptor-associated protein 16440 27.6 5.5 15.4 15.8 20.6 16.7 23.9 31.5
Src oncogene at 42A 11049 21.6 21.9 17.1 9.8 19.2 24.6 16.1 33.0
CG30482 9799 32.8 37.4 30.8 31.1 29.3 9.9 13.8 35.8
Canton-S (control)   37.6 32.9 34.9 31.5 31.8 35.7 28.4 34.4
  1. Bold numbers indicate longevity less than 1/3 of control. Parenthetical numbers indicate the mean longevity obtained from fewer than five flies.