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Table 2 Disease-related reduced-lifespan genes

From: A gain-of-function screen to identify genes that reduce lifespan in the adult of Drosophila melanogaster

Reduced-lifespan gene Human ortholog Homology (%)a Related diseases Reference
dream CASP9 28 Alzheimer’s disease, Cancer ROHN and HEAD [23], DEVARAJAN et al. [24]
Hepatocyte nuclear factor 4 HNF4alpha 67 Diabetes OMIM *600281
Calpain-A CAPN3 39 Muscular dystrophy OMIM *114240
embryonic lethal abnormal vision ELAVL4 53 Cancer, Anti-Hu syndrome SZABO et al. [25]
degringolade RNF4 42 Cancer HIRVONEN-SANTTI et al. [26], PERO et al. [27]
atlastin ATL1 56 Spastic paraplegia OMIM *606439
slipper MLK2 50 Huntington’s disease PHELAN et al. [28]
polo PLK1 52 Cancer STREBHARDT [29]
High mobility group protein D SSRP1 52 Cancer HUDSON et al. [30]
Fmr1 FXR1 49 Fragile X mental retardation VERKERK et al. [31]
Peroxin 16 PEX16 36 Zellweger syndrome OMIM *603360
Vacuolar H + ATPase subunit 100-2 ATP6V0A4 51 Distal renal tubular acidosis OMIM *605239
roadkill SPOP 79 Cancer LIU et al. [32]
CG8290 ATRX 36 ATRX (Xlinked αthalassemia with mental retardation) OMIM *300032
Lamin LMNA 38 More than a dozen different inherited diseases, including progeria syndrome OMIM *150330
Elongation factor Tu mitochondrial TUFM 66 Combined oxidative phosphorylation deficiency OMIM *602389
CG11819 UNC13D 23 Familial hemophagocytic lymphohistiocytosis-3 OMIM *608897
CG8032 SMOX 33 Cancer BABBAR and CASERO [33], GOODWIN et al. [34], XU et al. [35]
N-methyl-D-aspartate receptor-associated protein GRINA 46 Epilepsy BONAGLIA et al. [36]
Src oncogene at 42A FRK 61 Cancer HOSOYA et al. [37]
  1. aamino acid identity (%) between reduced-lifespan genes and their human orthologs.