Reduced-lifespan gene | Human ortholog | Homology (%)a | Related diseases | Reference |
---|---|---|---|---|
dream | CASP9 | 28 | Alzheimer’s disease, Cancer | |
Hepatocyte nuclear factor 4 | HNF4alpha | 67 | Diabetes | OMIM *600281 |
Calpain-A | CAPN3 | 39 | Muscular dystrophy | OMIM *114240 |
embryonic lethal abnormal vision | ELAVL4 | 53 | Cancer, Anti-Hu syndrome | SZABO et al. [25] |
degringolade | RNF4 | 42 | Cancer | |
atlastin | ATL1 | 56 | Spastic paraplegia | OMIM *606439 |
slipper | MLK2 | 50 | Huntington’s disease | PHELAN et al. [28] |
polo | PLK1 | 52 | Cancer | STREBHARDT [29] |
High mobility group protein D | SSRP1 | 52 | Cancer | HUDSON et al. [30] |
Fmr1 | FXR1 | 49 | Fragile X mental retardation | VERKERK et al. [31] |
Peroxin 16 | PEX16 | 36 | Zellweger syndrome | OMIM *603360 |
Vacuolar H + ATPase subunit 100-2 | ATP6V0A4 | 51 | Distal renal tubular acidosis | OMIM *605239 |
roadkill | SPOP | 79 | Cancer | LIU et al. [32] |
CG8290 | ATRX | 36 | ATRX (Xlinked αthalassemia with mental retardation) | OMIM *300032 |
Lamin | LMNA | 38 | More than a dozen different inherited diseases, including progeria syndrome | OMIM *150330 |
Elongation factor Tu mitochondrial | TUFM | 66 | Combined oxidative phosphorylation deficiency | OMIM *602389 |
CG11819 | UNC13D | 23 | Familial hemophagocytic lymphohistiocytosis-3 | OMIM *608897 |
CG8032 | SMOX | 33 | Cancer | |
N-methyl-D-aspartate receptor-associated protein | GRINA | 46 | Epilepsy | BONAGLIA et al. [36] |
Src oncogene at 42A | FRK | 61 | Cancer | HOSOYA et al. [37] |