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Table 1 Summary of reduced-lifespan genes

From: A gain-of-function screen to identify genes that reduce lifespan in the adult of Drosophila melanogaster

Reduced-lifespan gene GS number of 1st positive lines HS/no-HSc p35/GFPd
Transportin 11030a, 13069b 1.9/63.0 (3.02%) 3.0/4.1 (−)
Dream 16231a, b 1.3/34.6 (3.76%) 41.6/1.0 (+)
CG10277 11124a, b, 15951 1.9/50.0 (3.80%) 1.0/2.0 (−)
Hepatocyte nuclear factor 4 10535a, b 1.9/48.6 (3.91%) 2.9/41.3 (−)
Calpain-A 11846a, b 2.1/46.0 (4.57%) ND
Transfer RNA:ile:49Fb 14941a, b 3.0/65.1 (4.61%) 54.9/2.0 (+)
Combgap 11121a, b, 14406 2.0/43.0 (4.65%) 2.0/3.0 (−)
trpγ 16894a, b 1.8/36.8 (4.89%) 1.1/1.0 (−)
Apontic 15217a, b 2.2/44.8 (4.91%) 3.0/3.0 (−)
Cadmus 14710a, b 3.0/61.0 (4.92%) 2.7/3.8 (−)
PolyA-binding protein 13841, 15168a, b 2.4/46.7 (5.14%) 21.3/5.2 (+)
Embryonic lethal abnormal vision 5211a, b 2.6/43.6 (5.96%) 21.7/4.1 (+)
CG3363 11052a, b, 11427, 13243 3.0/49.0 (6.12%) 8.4/7.0 (−)
Stonewall 8015a, b, 16462, 17037 3.2/52.0 (6.15%) 6.8/21.2 (−)
Degringolade 3250, 15270a, b 3.0/48.6 (6.17%) 11.9/4.1 (−)
Atlastin 7264, 11283, 17467a 2.5/36.0 (6.94%) 2.0/1.7 (−)
Chromator 8043, 16669a, b, 17953 2.0/27.8 (7.19%) 3.3/3.1 (−)
Slipper 7470a, b 1.3/16.0 (8.13%) 31.9/1.0 (+)
Polo 16634a, b, 16673, 20105 3.9/44.8 (8.71%) 13.9/28.0 (−)
Without children 10711a, b 2.8/32.0 (8.75%) 8.1/2.1 (+)
Heterogeneous nuclear ribonucleoprotein at 27C 10478, 11696, 13072a, b, 13193, 14409, 14755, 16784, 16954 3.4/38.0 (8.95%) 22.3/36.5 (−)
High mobility group protein D 9106, 9272, 9689b, 10504, 10665a, 12910, 17197 2.6/25.0 (10.40%) 3.0/2.0 (−)
Fmr1 11128b, 11947a 5.0/45.0 (11.11%) 11.4/5.4 (−)
Peroxin 16 12435a, b, 14333, 15386 3.6/31.0 (11.61%) 17.4/22.1 (−)
Pipsqueak 12449a, b 6.7/51.1 (13.11%) 9.9/41.1 (−)
CG8290 12665a, b 4.7/34.9 (13.47%) 34.8/7.8 (+)
Vacuolar H + ATPase subunit 100-2 10911a, b, 14367 7.1/50.4 (14.09%) 2.8/31.6 (−)
CG10321 10668a, b 3.9/27.0 (14.44%) 3.2/4.4 (−)
Roadkill 14361, 14844, 15232, 15233a, b 6.3/41.8 (15.07%) 3.0/6.6 (−)
Lamin 16890a, b 4.5/28.3 (15.90%) 3.9/3.4 (−)
Elfless 15946a, b 3.3/20.0 (16.50%) 4.0/9.0 (−)
CG16779 9601a, b 4.4/26.0 (16.92%) 36.5/32.5 (−)
Elongation factor Tu mitochondrial 11862a, b 8.6/42.2 (20.38%) 14.9/20.1 (−)
CG11819 5065a, b 6.1/29.0 (21.03%) 22.7/14.8 (−)
Autophagy-specific gene 1 15847a, b 12.6/57.8 (21.80%) 21.8/5.0 (+)
CG8032 5196a, b 2.8/12.1 (23.14%) 46.9/8.3 (+)
N-methyl-D-aspartate receptor-associated protein 16440a, b 3.1/13.3 (23.31%) 2.8/17.7 (−)
Src oncogene at 42A 11022, 11049a, b 2.6/11.0 (23.64%) 4.5/5.4 (−)
CG30482 9799a, b 6.8/26.3 (25.86%) 5.0/28.5 (−)
Average   4.0/38.5 (10.40%) 13.5/11.6
  1. aRepresentative GS lines used for second screen. The mean longevities are listed on the third column (HS/no-HS).
  2. bGS lines used for p35 assay.
  3. cMean longevity (days) of heat-shocked (HS)/not-heat-shocked flies (no-HS).
  4. dMean longevity (days) of flies coexpressing p35 (p35)/or GFP (GFP). (+) indicates longevity extended more than three times by p35 as compared to GFP coexpression.