Figure 6

CD94 sufficiency does not alter IOP in D2 mice. In (A) the data is represented as a scatter plot, and in (B) as bar graphs of the mean IOP ± SEM (>30 mice). All groups contained at least 30 mice and included both males and females in similar proportions. Comparative analyses between the three genotypes showed that there were no significant differences in IOP (P > 0.05 for ages at 9 and 10 mo). At 12 mo time-point, only D2 Klrd1^+/- exhibited a slightly higher mean IOP (P = 0.046). Since IOP values between CD94 sufficient (D2 Klrd1^+/+) and deficient (D2 Klrd1^+/+) mice are comparable, this effect is unlikely to be dependent on genotype. A significant proportion of D2 mice typically show a drop in IOP at around 12 mo of age. The slight increase in mean IOP exhibited by D2 Klrd1^+/- mice is likely due to a high variability in IOP values as a consequence of their crashing in some mice. Age related ciliary-body atrophy is though to contribute to this IOP drop at around 12 mo in D2 mice.