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Table 3 Interaction between vitamin D receptor ( VDR ) and retinoid X receptor-gamma ( RXRG ) polymorphisms in the replication cohorts (Northern Finland Birth Cohort 1966 and Twins UK)

From: Interaction between allelic variations in vitamin D receptor and retinoid X receptor genes on metabolic traits

Outcome

VDR

RXRG

Northern Finland Birth Cohort 1966 (NFBC66)

Twins UK

Meta-analysis of the results from NFBC66 and Twins UK

 

SNP

SNP

        
   

N in analysis

Interaction Beta ± SE

Pinteraction

N in analysis

Interaction Beta ± SE

Pinteraction

Interaction Beta ± SE

Unadjusted Pinteraction(Adjusted Pinteraction*)

Low density lipoprotein cholesterol

rs3847987

rs283695

5,007

−0.03 ± 0.03

0.26

1,555

−0.08 ± 0.08

0.31

−0.04 ± 0.03

0.16

rs11574143

rs283695

4,990

−0.02 ± 0.03

0.52

1,528

−0.03 ± 0.08

0.75

−0.02 ± 0.03

0.48

Serum triglycerides

rs11574143

rs17429123

5,155

0.01 ± 0.03

0.74

1,686

0.09 ± 0.06

0.13

0.03 ± 0.03

0.32

rs11574143

rs10918172

5,131

0.03 ± 0.03

0.28

1,725

0.05 ± 0.05

0.37

0.04 ± 0.03

0.16

rs3847987

rs17429123

5,172

0.03 ± 0.03

0.28

1,730

0.08 ± 0.05

0.09

0.05 ± 0.02

0.08

rs3847987

rs10918172

5,148

0.05 ± 0.03

0.07

1,767

0.07 ± 0.05

0.14

0.06 ± 0.03

0.02 (0.17)

rs739837, rs2238136

rs1273959

5,204

−0.002 ± 0.03

0.95

1,883

0.01 ± 0.04

0.79

0.003 ± 0.03

0.91

Waist hip ratio

rs2283342

rs157872

4,707

0.002 ± 0.003

0.53

3,376

−0.002 ± 0.004

0.62

0.001 ± 0.002

0.78

  1. *Bonferroni correction applied to Pinteraction values.