Associations between variants of FADS genes and omega-3 and omega-6 milk fatty acids of Canadian Holstein cows

Ibeagha-Awemu, Eveline M; Akwanji, Kingsley A; Beaudoin, Frédéric; Zhao, Xin

doi:10.1186/1471-2156-15-25

BMC Genomic Data

Table 2 Results of significant ¹ marker associations with milk fatty acid isomers (g/100 g of total fat) of Canadian Holstein cows

From: Associations between variants of FADS genes and omega-3 and omega-6 milk fatty acids of Canadian Holstein cows

Trait		SNP²		Means of genotypes³						Max SEM⁴	P-value	FDR⁵
Fatty acid	Common name	Lab Id	rs#	CC	CT	TT	AA	AG	GG			FDR⁵
Fatty acid	Common name	Lab Id	rs#	CC	CT	TT	AA	AG	GG			P-value
Polyunsaturated fatty acids
C18:2n10t12c	CLA: 10t12c	FADS2-19	rs210169303	0.024^a	0.023^ab	0.021^b	-	-	-	0.001	0.027	0.189
C18:2n6tt	Trans linoleic acid	FADS1-07	rs42187261	0.158^ab	0.157^a	0.170^b	-	-	-	0.006	0.034	0.176
		FADS2-19	rs210169303	0.165^a	0.158^ab	0.147^b	-	-	-	0.008	0.050	0.176
C20:3n6	Dihomogamma linolenic acid	FADS1-01	rs136261927	0.095^a	0.087^b	0.075^b	-	-	-	0.007	0.0003	0.002
	Dihomogamma linolenic acid	FADS1-07	rs42187261	0.090^ab	0.089^a	0.096^b	-	-	-	0.003	0.024	0.056
		FADS2-23	rs109772589	-	-	-	0.089^a	0.096^b	0.108^b	0.007	0.001	0.003
C20:4n6	Arachidonic acid	FADS1-07	rs42187261	0.114^a	0.116^a	0.122^b	-	-	-	0.003	0.021	0.074
		FADS2-23	rs109772589	-	-	-	0.115^a	0.123^b	0.126^ab	0.007	0.002	0.013
C20:5n3	Eicosapentaenoic acid	FADS1-07	rs42187261	0.036^ab	0.033^a	0.037^b	-	-	-	0.001	0.004	0.029
Monounsaturated fatty acids
C14:1 t	Myristelaidic acid	FADS2-23	rs109772589	-	-	-	0.247^ab	0.259^a	0.213^b	0.019	0.029	0.204
C18:1 total		FADS1-07	rs42187261	24.458^a	24.439^a	23.106^b	-	-	-	0.544	0.012	0.084
C18:1n9c	Oleic acid	FADS1-07	rs42187261	21.419^a	21.374^a	20.089^b	-	-	-	0.520	0.011	0.074
Total MUFA		FADS1-07	rs42187261	30.598^a	30.669^a	29.207^b	-	-	-	0.620	0.019	0.131
Saturated fatty acids
C8:0	Caprylic acid	FADS1-07	rs42187261	0.876^a	0.883^a	0.921^b	-	-	-	0.020	0.043	0.301
C11:0	Undecanoic acid	FADS1-07	rs42187261	0.217^a	0.221^a	0.238^b	-	-	-	0.007	0.017	0.116
C15:0	Pentadecylic acid	FADS1-08	rs41652284	1.147^a	1.098^a	1.262^b	-	-	-	0.058	0.010	0.072
C17:0	Margaric acid	FADS1-08	rs41652284	0.669^ab	0.658^a	0.698^b	-	-	-	0.016	0.031	0.219
C23:0	Tricosanoic acid	FADS1-07	rs42187261	0.024^a	0.023^a	0.028^b	-	-	-	0.001	0.002	0.011
Total SFA		FADS1-07	rs42187261	66.155^ab	66.051^a	67.542^b	-	-	-	0.638	0.021	0.147

¹For significant associations, P-values and FDR P-values (P≤0.05) are shown.
²Lab Id = lab notation of SNPs, rs# = SNP data base identification number of SNPs.
³For each trait, genotype means (g/100 g of total fat) with different superscripts differ significantly (P ≤ 0.05). Genotype frequencies are listed in Table 2.
⁴Maximum standard error of the mean.
⁵FDR = False discovery rate.

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