Table 1 Overview of the 12 examined VKORC1 variants detected in mice and rats

Arg12Trp

Mus musculus, Mus spretus[15, 18]

2D: tendency to random coil

3D: clash of side chain

Ser56Pro

Rattus norvegicus[14]

2D: tendency to random coil

3D: clash of side chain, less hydrogen bonds

Trp59Arg

Rattus spec.[15, 19]

2D: tendency to random coil

3D: change of side chain for ligand

Arg61Leu

Mus musculus, Mus spretus[15, 18]

2D: tendency to beta strand

3D: no important differences

Phe63Cys

Rattus spec.[15, 19]

2D: tendency to beta strand

3D: clash of side chain

Glu67Lys

Rattus spec.[15, 19]

2D, 3D: no important differences

Leu120Gln

Rattus norvegicus[14]

2D: conversion of helix to beta strand

3D: missing side chain for ligand binding

Leu128Gln

Rattus spec.[14, 15, 19]

2D: partial conversion of helix to beta strand

3D: no differences, interaction with ligand?

Leu128Ser

Mus musculus[14, 15]

2D: partial conversion of helix to beta strand

3D: no differences, interaction with ligand?

Tyr139Cys

Rattus spec., Mus musculus[14, 15, 19]

2D: tendency to beta strand

3D: no differences, interaction with ligand?

Tyr139Phe

Rattus spec.[14, 15, 19]

2D, 3D: no differences, interaction with ligand?

Tyr139Ser

Rattus spec.[14, 15, 19]

2D: tendency to random coil

3D: no differences, interaction with ligand?