|  | Non- diabetic | Diabetic | p interaction | ||||
---|---|---|---|---|---|---|---|---|
Allele | Phenotype | Effects size | 95% CI | p | Effects size | 95% CI | p | Â |
IRS1 A | Fasting glucose | 0.09 | −0.11 to 0.30 | 0.372 | −0.53 | −2.96 to 1.90 | 0.668 | 0.330 |
 | 2 h glucose | 0.08 | −0.36 to 0.51 | 0.723 | 2.33 | −2.09 to 6.75 | 0.304 | 0.038 |
 | HbA1c | 0.02 | −0.10 to 0.14 | 0.746 | 0.13 | −1.04 to 1.31 | 0.823 | 0.853 |
 | Fasting insulin | −1.02 | −3.76 to 1.71 | 0.463 | −3.27 | −20.75 to 14.21 | 0.714 | 0.690 |
 | 2 h insulin | 1.62 | −15.50 to 18.75 | 0.853 | 2.36 | −63.13 to 67.86 | 0.944 | 0.944 |
 | Glucose/insulin | −0.14 | −2.26 to 1.97 | 0.894 | 0.30 | −8.40 to 9.00 | 0.946 | 0.896 |
 | HOMA-IR | −0.22 | −0.87 to 0.42 | 0.498 | −2.03 | −9.96 to 5.91 | 0.617 | 0.448 |
 | QUICKI | 0.002 | −0.015 to 0.018 | 0.857 | −0.001 | −0.025 to 0.022 | 0.903 | 0.877 |
 | FIRI | −0.20 | −0.78 to 0.38 | 0.480 | −1.82 | −8.97 to 5.31 | 0.617 | 0.448 |
PPARG C | Fasting glucose | −0.06 | −0.26 to 0.13 | 0.528 | 0.003 | −1.71 to 1.72 | 0.995 | 0.970 |
 | 2 h glucose | −0.02 | −0.44 to 0.41 | 0.933 | −2.46 | −5.68 to 0.76 | 0.137 | 0.002 |
 | HbA1c | 0.07 | −0.04 to 0.19 | 0.216 | −0.18 | 1.02 to 0.65 | 0.663 | 0.362 |
 | Fasting insulin | −0.56 | −3.21 to 2.09 | 0.617 | −5.72 | −18.00 to 6.57 | 0.363 | 0.283 |
 | 2 h insulin | 34.0 | 15.9 to 52.2 | 0.0003 | −14.4 | −64.7 to 35.8 | 0.575 | 0.017 |
 | Glucose/insulin | −0.21 | −2.26 to 1.83 | 0.840 | −2.62 | −8.82 to 3.37 | 0.407 | 0.307 |
 | HOMA-IR | −0.12 | 0.74 to 0.51 | 0.714 | −2.31 | −7.89 to 3.27 | 0.417 | 0.299 |
 | QUICKI | 0.0001 | −0.015 to 0.016 | 0.924 | −0.007 | −0.024 to 0.009 | 0.377 | 0.481 |
 | FIRI | −0.10 | −0.67 to 0.46 | 0.714 | −2.08 | −7.10 to 2.94 | 0.417 | 0.299 |