Table 6 Conditional probabilities of parent-child dyad genotypes given the sampling scheme of using the affected child as a proband
From: Association analysis of complex diseases using triads, parent-child dyads and singleton monads
Genotype | P(G, C ∣ D), G = M or F, | P(G, C ∣ D), | # Obs | |
|---|---|---|---|---|
ParentG | CaseC | complex version | simplified version | |
AA | AA | p4ψ 2 /R + 2p3q ψ 2 /(2R) | p3ψ 2 /R | m 1 |
Aa | 2p3q ψ 1 /(2R) + p2q2ψ 1 /R | p2q ψ 1 /R | m 2 | |
AA | 2p3q ψ 2 /(2R) + 4p2q2ψ 2 /(4R) | p2q ψ 2 /R | m 3 | |
Aa | Aa | 2p3q ψ 1 /(2R) + 4p2q2(2ψ 1 )/(4R) + 2p q3ψ 1 /(2R) | p q ψ 1 /R | m 4 |
aa | 4p2q2/(4R) + 2p q3/(2R) | p q2/R | m 5 | |
aa | Aa | p2q2ψ 1 /R + 2p q3ψ 1 /(2R) | p q2ψ 1 /R | m 6 |
aa | 2p q3/(2R) + q4/R | q3/R | m 7 | |
Total | 1 | 1 | m | |