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Table 4 Results of the proposed likelihood ratio tests of SNP rs2166975 and parameter estimates in the region of gene TGFA for cleft palate only data in Carter et al. [[1]]

From: Association analysis of complex diseases using triads, parent-child dyads and singleton monads

Model Data used MLEs Test results
Unr   p ̂ ( p ~ , ψ 1 ~ , ψ ~ 2 ) LRT p-value
FT + PD + AM 0.250 (0.226, 1.260, 1.660) 3.821 0.148
FT + PD 0.246 (0.226, 1.279, 1.413) 2.994 0.224
FT 0.245 (0.221, 1.365,1.508) 4.077 0.130
Rec   p ̂ ( p ~ , ψ ~ 2 ) LRT p-value
FT + PD + AM 0.250 (0.243, 1.295) 1.245 0.265
FT + PD 0.246 (0.244, 1.087) 0.116 0.733
FT 0.245 (0.243, 1.095) 0.113 0.737
Dom   p ̂ ( p ~ , ψ ~ 1 ) LRT p-value
FT + PD + AM 0.250 (0.233, 1.247) 2.407 0.121
FT + PD 0.246 (0.228, 1.275) 2.829 0.093
FT 0.245 (0.224, 1.362) 3.938 0.047
Mult   p ̂ ( p ~ , ψ ~ 1 ) LRT p-value
FT + PD + AM 0.250 (0.226, 1.275) 3.792 0.051
FT + PD 0.246 (0.226, 1.232) 2.711 0.100
FT 0.245 (0.221, 1.292) 3.585 0.058
Add   p ̂ ( p ~ , ψ ~ 1 ) LRT p-value
FT + PD + AM 0.250 (0.226, 1.281) 3.688 0.055
FT + PD 0.246 (0.225, 1.256) 2.847 0.092
FT 0.245 (0.220, 1.332) 3.830 0.050
  1. The Sub-sample sizes are n = 296, m = 62, s = 15, (n 1 , n 2 , n 3 , n 4 , n 5 , n 6 , n 7 , n 8 , n 9 , n 10 ) = (0, 6, 5, 19, 13, 30, 6, 67, 54, 96), (m 1 , m 2 , m 3 , m 4 , m 5 , m 6 , m 7 ) = (0, 3, 4, 11,11, 8, 25), and (s0, s1, s2) = (7, 3, 5). Abbreviations: FT = Full triads, PD = Parent-child dyads, and AM = Affected monads.