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Table 2 Predictors of DNA Yield (log_e transformed) in children

From: Predictors of mother and child DNA yields in buccal cell samples collected in pediatric cancer epidemiologic studies: a report from the Children’s Oncology group

  HB (N = 412) Infant Leukemia (N = 392) Combined (N = 804)
  βa(95% CI) % changeb Pvalue βa % changeb Pvalue βa % changeb Pvalue
Age at DNA collection (years)         
0 – 2 0.60 (−0.27-1.47) 81 0.18 0.81 (−0.37-1.99) 125 0.18 0.67 (−0.09-1.42) 95 0.08
2 – 5 −0.10 (−0.65-0.46) −9.1 0.74 −0.76 (−1.72-0.20) −53 0.12 −0.42 (−0.97-0.12) −34 0.13
> 5 years Reference Reference   Reference Reference   Reference Reference  
Child’s sex          
Male Reference Reference   Reference Reference   Reference Reference  
Female 0.06 (−0.42-0.55) 6.6 0.80 0.47 (−0.35-1.28) 60 0.26 0.31 (−0.17-0.78) 36 0.21
Study          
HB NA NA NA NA NA NA Reference Reference  
Infant leukemia NA NA NA NA NA NA −1.05 (−1.60- -0.51) −65 0.0002
Case control status         
Control Reference Reference   Reference Reference   Reference Reference  
Case −0.65 (−1.18- -0.11) −48 0.01 −0.64 (−1.52-0.25) −42 0.16 −0.69 (−1.20- -0.17) −50 0.01
Collection type          
Cytosoft brush Reference Reference   Reference Reference   Reference Reference  
Epicentre brush 0.94 (0.43-1.45) 160 0.0003 2.46 (1.15-3.76) 1070 0.0002 1.23 (0.64-1.81) 242 <0.0001
Mouthwash 4.22 (3.26-5.17) 6670 <0.0001 NA   NA 4.42 (3.16-5.67) 8210 <0.0001
Maternal race          
White Reference Reference   Reference Reference   Reference Reference  
Other −0.66 (−1.24- -0.08) −49 0.03 0.36 (−0.75-1.47) 43 0.52 −0.19 (−0.80-0.42) −17 0.52
Season of DNA collection         
Spring Reference Reference   Reference Reference   Reference Reference  
Summer −0.89 (−1.52- -0.26) −59 0.006 −3.85 (−5.03- -2.66) −97 <0.0001 −2.06 (−2.71- -1.42) −87 <0.0001
Fall −0.36 (−1.05-0.33) −30 0.31 −1.56 (−2.67- -0.45) −79 0.006 −0.84 (−1.50- -0.19) −57 0.01
Winter 0.01 (−0.67-0.70) 1.5 0.97 1.02 (−0.13-2.17) 469 0.08 0.54 (−0.13-1.22) 72 0.11
  1. a Models were adjusted for all other variables in table.
  2. b Percent change in DNA yield compared to referent.
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BMC Genomic Data

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