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Table 2 Predictors of DNA Yield (log_e transformed) in children

From: Predictors of mother and child DNA yields in buccal cell samples collected in pediatric cancer epidemiologic studies: a report from the Children’s Oncology group

 

HB (N = 412)

Infant Leukemia (N = 392)

Combined (N = 804)

 

βa(95% CI)

% changeb

Pvalue

βa

% changeb

Pvalue

βa

% changeb

Pvalue

Age at DNA collection (years)

        

0 – 2

0.60 (−0.27-1.47)

81

0.18

0.81 (−0.37-1.99)

125

0.18

0.67 (−0.09-1.42)

95

0.08

2 – 5

−0.10 (−0.65-0.46)

−9.1

0.74

−0.76 (−1.72-0.20)

−53

0.12

−0.42 (−0.97-0.12)

−34

0.13

> 5 years

Reference

Reference

 

Reference

Reference

 

Reference

Reference

 

Child’s sex

         

Male

Reference

Reference

 

Reference

Reference

 

Reference

Reference

 

Female

0.06 (−0.42-0.55)

6.6

0.80

0.47 (−0.35-1.28)

60

0.26

0.31 (−0.17-0.78)

36

0.21

Study

         

HB

NA

NA

NA

NA

NA

NA

Reference

Reference

 

Infant leukemia

NA

NA

NA

NA

NA

NA

−1.05 (−1.60- -0.51)

−65

0.0002

Case control status

        

Control

Reference

Reference

 

Reference

Reference

 

Reference

Reference

 

Case

−0.65 (−1.18- -0.11)

−48

0.01

−0.64 (−1.52-0.25)

−42

0.16

−0.69 (−1.20- -0.17)

−50

0.01

Collection type

         

Cytosoft brush

Reference

Reference

 

Reference

Reference

 

Reference

Reference

 

Epicentre brush

0.94 (0.43-1.45)

160

0.0003

2.46 (1.15-3.76)

1070

0.0002

1.23 (0.64-1.81)

242

<0.0001

Mouthwash

4.22 (3.26-5.17)

6670

<0.0001

NA

 

NA

4.42 (3.16-5.67)

8210

<0.0001

Maternal race

         

White

Reference

Reference

 

Reference

Reference

 

Reference

Reference

 

Other

−0.66 (−1.24- -0.08)

−49

0.03

0.36 (−0.75-1.47)

43

0.52

−0.19 (−0.80-0.42)

−17

0.52

Season of DNA collection

        

Spring

Reference

Reference

 

Reference

Reference

 

Reference

Reference

 

Summer

−0.89 (−1.52- -0.26)

−59

0.006

−3.85 (−5.03- -2.66)

−97

<0.0001

−2.06 (−2.71- -1.42)

−87

<0.0001

Fall

−0.36 (−1.05-0.33)

−30

0.31

−1.56 (−2.67- -0.45)

−79

0.006

−0.84 (−1.50- -0.19)

−57

0.01

Winter

0.01 (−0.67-0.70)

1.5

0.97

1.02 (−0.13-2.17)

469

0.08

0.54 (−0.13-1.22)

72

0.11

  1. a Models were adjusted for all other variables in table.
  2. b Percent change in DNA yield compared to referent.