Table 2 Predictors of DNA Yield (log_e transformed) in children
HB (N = 412) | Infant Leukemia (N = 392) | Combined (N = 804) | |||||||
|---|---|---|---|---|---|---|---|---|---|
βa(95% CI) | % changeb | Pvalue | βa | % changeb | Pvalue | βa | % changeb | Pvalue | |
Age at DNA collection (years) | |||||||||
0 – 2 | 0.60 (−0.27-1.47) | 81 | 0.18 | 0.81 (−0.37-1.99) | 125 | 0.18 | 0.67 (−0.09-1.42) | 95 | 0.08 |
2 – 5 | −0.10 (−0.65-0.46) | −9.1 | 0.74 | −0.76 (−1.72-0.20) | −53 | 0.12 | −0.42 (−0.97-0.12) | −34 | 0.13 |
> 5 years | Reference | Reference | Reference | Reference | Reference | Reference | |||
Child’s sex | |||||||||
Male | Reference | Reference | Reference | Reference | Reference | Reference | |||
Female | 0.06 (−0.42-0.55) | 6.6 | 0.80 | 0.47 (−0.35-1.28) | 60 | 0.26 | 0.31 (−0.17-0.78) | 36 | 0.21 |
Study | |||||||||
HB | NA | NA | NA | NA | NA | NA | Reference | Reference | |
Infant leukemia | NA | NA | NA | NA | NA | NA | −1.05 (−1.60- -0.51) | −65 | 0.0002 |
Case control status | |||||||||
Control | Reference | Reference | Reference | Reference | Reference | Reference | |||
Case | −0.65 (−1.18- -0.11) | −48 | 0.01 | −0.64 (−1.52-0.25) | −42 | 0.16 | −0.69 (−1.20- -0.17) | −50 | 0.01 |
Collection type | |||||||||
Cytosoft brush | Reference | Reference | Reference | Reference | Reference | Reference | |||
Epicentre brush | 0.94 (0.43-1.45) | 160 | 0.0003 | 2.46 (1.15-3.76) | 1070 | 0.0002 | 1.23 (0.64-1.81) | 242 | <0.0001 |
Mouthwash | 4.22 (3.26-5.17) | 6670 | <0.0001 | NA | NA | 4.42 (3.16-5.67) | 8210 | <0.0001 | |
Maternal race | |||||||||
White | Reference | Reference | Reference | Reference | Reference | Reference | |||
Other | −0.66 (−1.24- -0.08) | −49 | 0.03 | 0.36 (−0.75-1.47) | 43 | 0.52 | −0.19 (−0.80-0.42) | −17 | 0.52 |
Season of DNA collection | |||||||||
Spring | Reference | Reference | Reference | Reference | Reference | Reference | |||
Summer | −0.89 (−1.52- -0.26) | −59 | 0.006 | −3.85 (−5.03- -2.66) | −97 | <0.0001 | −2.06 (−2.71- -1.42) | −87 | <0.0001 |
Fall | −0.36 (−1.05-0.33) | −30 | 0.31 | −1.56 (−2.67- -0.45) | −79 | 0.006 | −0.84 (−1.50- -0.19) | −57 | 0.01 |
Winter | 0.01 (−0.67-0.70) | 1.5 | 0.97 | 1.02 (−0.13-2.17) | 469 | 0.08 | 0.54 (−0.13-1.22) | 72 | 0.11 |