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Table 1 Definition and size of the classes

From: iXora: exact haplotype inferencing and trait association

 

Accuracy %

Trait

Time

 
 

PA (ua)

Imp. (ua)

PHA %

Assoc.

Sec

Remarks

 

Unrelated individuals (no parent information)

fastPHASE [6]

60.07(0.00)

59.77(0.00)

NA

No

78

 
 

58.01(0.00)

56.55(0.00)

  

158

 

FMPH [12]

-

-

NA

No

-

Up to 30-100 markers

MACH [9]

52.89 (0.00)

52:16(0:00)

NA

Yes

567

 
 

52.49 (0.00)

50.91 (0.00)

  

1144

 
 

Unrelated trios

BEAGLE [5]

99.90 (0.00)

98.61 (0.00)

NA

Yes

5

 
 

99.90 (0.00)

98.28 (0.00)

  

10

 

HAPI-UR [8]

99.69 (0.00)

94.75 (0.00)

NA

No

3

 
 

99.67 (0.00)

94.88 (0.00)

  

7

 
 

Related trios

HAPI [7]

90.75 (9.17)

0.00 (100.0)

83.88

No

0.1

< 15 progeny/parent

 

90:63(9:29)

0:00(100:0)

83.87

 

0.2

 

Merlin [13]

70:59(29:38)

69:60(29:47)

69.74

Yes

299

< 15 progeny/parent

 

64:80(35:18)

63:72(35:09)

63.81

 

604

 

SHAPEIT2 [11]

87:20(0:00)

57:61(0:00)

NA

No

70

< 50 progeny/parent

 

90:46(0:00)

64:05(0:00)

  

148

 

iXora

95:89(4:05)

92:11(7:75))

95.55

Yes

0.3

 
 

95:73(4:21)

91:43(8:40)

95.43

 

0.8

 
  1. The first row for each method corresponds to 300 markers while the second to 600 markers. The results are averaged over multiple data sets of 200 individuals. Parental haplotype assignment (PHA) was found to be critical in the task of trait association in [15] and is shown here in bold font. Section Methods describes accuracy and PHA computation in detail. Trait assoc. denotes whether the software allows testing for phenotype association. Time was obtained on a system with 3.0 GHz quad-core processor and 4 GB memory. Abbreviations: PA= Parent assignment; Imp. = Imputation; PHA = Parent haplotype assignment; ua = unassigned; "NA” = computation is outside the scope of the software; "-” = unable to compute on our data sets