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Table 2 False positive and true positive rates via TotD| M , when v / μ is not known in advance

From: Detecting negative selection on recurrent mutations using gene genealogy

A. v/μ=0.

     

θ μ

σ=0(neutral)

σ = − 10

σ = − 103/2

σ = − 102

σ = − 105/2

10-1

0.055

0.063

0.182

NA

NA

10-1/2

0.059

0.052

0.162

0.333

NA

1(=100)

0.005

0.097

0.294

0.521

0.615

10+1/2

NAa

0.021

0.208

0.543

0.774

10+1

NA

NA

0.008

0.488

0.699

B. v/μ=1.

     

θ μ

σ=0 (neutral)

σ = − 10

σ = − 103/2

σ = − 102

σ = − 105/2

10-1

0.057

0.063

NA

NA

NA

10-1/2

0.038

0.175

0.203

0.625

NA

1(=100)

0.028

0.110

0.339

0.519

0.739

10+1/2

0.009

0.058

0.266

0.497

0.706

10+1

0.000

0.002

0.081

0.527

0.728

C. v/μ=3.

     

θ μ

σ=0 (neutral)

σ = − 10

σ = − 103/2

σ = − 102

σ = − 105/2

10-1

0.051

0.000

NA

NA

NA

10-1/2

0.037

0.118

0.351

0.500

NA

1(=100)

0.037

0.140

0.240

0.528

0.815

10+1/2

0.050

0.131

0.293

0.547

0.746

10+1

0.078

0.142

0.293

0.585

0.734

  1. NOTE. Here, n=100 and α = 1, as well as 5% nominal significance level, are fixed. The tables show proportions of loci that tested positive via TotD| M out of those whose gene genealogies revealed recurrent mutations. ν/μ is the backward/forward ratio of mutation rates. θ μ (≡ 4) is the rescaled forward mutation rate. σ(≡ 4Ns) denotes the rescaled selection coefficient.
  2. a “NA” is assigned to a category with less than 10 loci with revealed recurrent mutations.