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Table 5 Summary of single QTL scans in BC- A y mice

From: Genetic background (DDD/Sgn versus C57BL/6J) strongly influences postnatal growth of male mice carrying the Ayallele at the agouti locus: identification of quantitative trait loci associated with diabetes and body weight loss

Trait

Chromosome

Location (cM)a

95% CI (cM)b

Max LODc

Nearest marker

High alleled

Body weight at 25 weeks

1

56

45–73

2.69*

D1Mit102

B6

 

4

61

41–61

4.25*

D4Mit234

B6

 

6

44

0–56

1.44

D6Mit108

B6

 

15

80

0–80

1.39

D15Mit193

DDD

BMI

1

56

0–73

1.48

D1Mit102

B6

 

4

55

36–61

4.77*

D4Mit234

B6

 

6

45

0–56

2.16

D6Mit256

B6

Blood glucose

4

61

21–61

1.88

D4Mit234

DDD

 

7.1

0

na

1.54

D7Mit250

B6

 

12

30

0–49

1.82

D12Mit259

B6

Plasma glucose

4

61

13–65

1.55

D4Mit234

DDD

 

7.1

0

na

1.56

D7Mit250

B6

 

12

30

10–49

2.28

D12Mit259

B6

 

19

11

0–35

1.73

D19Mit32

DDD

Plasma triglyceride

8

14

0–28

1.77

D8Mit249

DDD

 

12

27

7–44

2.39

D12Mit259

DDD

 

18

0

0–71

1.42

D18Mit21

DDD

HMW adiponectin

4

39

10–61

1.89

D4Mit12

B6

 

7.1

0

na

1.57

D7Mit250

DDD

  1. aLocation indicates a chromosomal position showing a peak LOD score in cM.
  2. b95% CI is defined by a 1.5-LOD support interval. na, not available.
  3. cMaximum LOD score for QTL. Significant QTLs are indicated by * (suggestive QTLs are shown without asterisks).
  4. dAllele associated with higher trait values.