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Table 2 Correlation analyses, between ecological variables and CYP3A5 allelic and inferred expression data

From: Molecular diversity and population structure at the Cytochrome P450 3A5 gene in Africa

Time period Ecological variable N=87 N=36
   CYP3A5*3 CYP3A5*6 CYP3A5*7 High expresser allele (assuming CYP3A5*6 is a low/non-expresser allele) Low expresser allele (assuming CYP3A5*6 is a low/non-expresser allele) High expresser allele (assuming CYP3A5*6 is not a low/non-expresser allele) Low expresser allele (assuming CYP3A5*6 is not a low/non-expresser allele)
   Rho P -value Rho P -value Rho P -value Rho P -value Rho P -value Rho P -value Rho P -value
  Latitude 0.706 <0.0001 −0.331 0.048 −0.177 0.303 −0.472 0.004 0.472 0.004 −0.416 0.012 0.416 0.012
  North latitude 0.666 <0.0001 −0.621 0.001 −0.410 0.047 −0.659 <0.0001 0.659 <0.0001 −0.620 0.001 0.620 0.001
  South latitude 0.066 0.759 0.318 0.130 0.122 0.571 −0.701 <0.0001 0.701 <0.0001 −0.370 0.075 0.370 0.075
  Temperature −0.664 <0.0001 0.268 0.114 0.494 0.002 0.655 <0.0001 −0.655 <0.0001 0.627 <0.0001 −0.627 <0.0001
Present Day Precipitation −0.129 0.232 −0.290 0.867 −0.150 0.384 −0.028 0.869 0.028 0.869 0.113 0.511 −0.113 0.511
  Aridity 0.286 0.007 −0.201 0.24 −0.267 0.116 −0.185 0.279 0.185 0.279 −0.029 0.868 0.029 0.868
  Temperature −0.597 <0.0001 0.216 0.207 0.342 0.041 0.560 0.0004 −0.560 0.0003 0.635 <0.0001 −0.635 <0.0001
Holocene Precipitation 0.072 0.510 −0.235 0.167 −0.522 0.001 −0.381 0.022 0.381 0.022 −0.190 0.266 0.190 0.266
  Aridity 0.471 <0.0001 −0.344 0.04 −0.575 0.0002 −0.465 0.004 0.465 0.004 −0.293 0.083 0.293 0.0832
  Temperature −0.644 <0.0001 0.297 0.079 0.608 <0.0001 0.649 <0.0001 −0.649 <0.0001 0.641 <0.0001 −0.641 <0.0001
Late Pleistocene Precipitation 0.160 0.139 −0.238 0.163 −0.353 0.035 −0.204 0.233 0.204 0.233 −0.023 0.892 0.023 0.892
  Aridity 0.532 <0.0001 −0.436 0.008 −0.480 0.003 −0.379 0.026 0.379 0.023 −0.211 0.216 0.211 0.216
  1. For analyses with inferred CYP3A5 expression phenotypes high-, intermediate- and low- expression diplotypes were counted as genotypes and the frequencies of expresser and low/non-expresser alleles calculated. For analyses with phenotypes, CYP3A5*6 was considered to cause low/non-expression and to have no effect on CYP3A5 expression. Significant p-values, at the 5% level, are shown in bold. Rho indicates Spearmann’s Rho. “N” refers to the number of populations analyzed for each CYP3A5 allele. For CYP3A5*3 frequencies, African data were combined with those previously reported [20]. For CYP3A5*6 and CYP3A5*7 correlations, only African data genotyped for this study were tested. North latitude and south latitude correlations were only performed with populations genotyped for this study.