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Table 2 Correlation analyses, between ecological variables and CYP3A5 allelic and inferred expression data

From: Molecular diversity and population structure at the Cytochrome P450 3A5 gene in Africa

Time period

Ecological variable

N=87

N=36

  

CYP3A5*3

CYP3A5*6

CYP3A5*7

High expresser allele (assuming CYP3A5*6 is a low/non-expresser allele)

Low expresser allele (assuming CYP3A5*6 is a low/non-expresser allele)

High expresser allele (assuming CYP3A5*6 is not a low/non-expresser allele)

Low expresser allele (assuming CYP3A5*6 is not a low/non-expresser allele)

  

Rho

P -value

Rho

P -value

Rho

P -value

Rho

P -value

Rho

P -value

Rho

P -value

Rho

P -value

 

Latitude

0.706

<0.0001

−0.331

0.048

−0.177

0.303

−0.472

0.004

0.472

0.004

−0.416

0.012

0.416

0.012

 

North latitude

0.666

<0.0001

−0.621

0.001

−0.410

0.047

−0.659

<0.0001

0.659

<0.0001

−0.620

0.001

0.620

0.001

 

South latitude

0.066

0.759

0.318

0.130

0.122

0.571

−0.701

<0.0001

0.701

<0.0001

−0.370

0.075

0.370

0.075

 

Temperature

−0.664

<0.0001

0.268

0.114

0.494

0.002

0.655

<0.0001

−0.655

<0.0001

0.627

<0.0001

−0.627

<0.0001

Present Day

Precipitation

−0.129

0.232

−0.290

0.867

−0.150

0.384

−0.028

0.869

0.028

0.869

0.113

0.511

−0.113

0.511

 

Aridity

0.286

0.007

−0.201

0.24

−0.267

0.116

−0.185

0.279

0.185

0.279

−0.029

0.868

0.029

0.868

 

Temperature

−0.597

<0.0001

0.216

0.207

0.342

0.041

0.560

0.0004

−0.560

0.0003

0.635

<0.0001

−0.635

<0.0001

Holocene

Precipitation

0.072

0.510

−0.235

0.167

−0.522

0.001

−0.381

0.022

0.381

0.022

−0.190

0.266

0.190

0.266

 

Aridity

0.471

<0.0001

−0.344

0.04

−0.575

0.0002

−0.465

0.004

0.465

0.004

−0.293

0.083

0.293

0.0832

 

Temperature

−0.644

<0.0001

0.297

0.079

0.608

<0.0001

0.649

<0.0001

−0.649

<0.0001

0.641

<0.0001

−0.641

<0.0001

Late Pleistocene

Precipitation

0.160

0.139

−0.238

0.163

−0.353

0.035

−0.204

0.233

0.204

0.233

−0.023

0.892

0.023

0.892

 

Aridity

0.532

<0.0001

−0.436

0.008

−0.480

0.003

−0.379

0.026

0.379

0.023

−0.211

0.216

0.211

0.216

  1. For analyses with inferred CYP3A5 expression phenotypes high-, intermediate- and low- expression diplotypes were counted as genotypes and the frequencies of expresser and low/non-expresser alleles calculated. For analyses with phenotypes, CYP3A5*6 was considered to cause low/non-expression and to have no effect on CYP3A5 expression. Significant p-values, at the 5% level, are shown in bold. Rho indicates Spearmann’s Rho. “N” refers to the number of populations analyzed for each CYP3A5 allele. For CYP3A5*3 frequencies, African data were combined with those previously reported [20]. For CYP3A5*6 and CYP3A5*7 correlations, only African data genotyped for this study were tested. North latitude and south latitude correlations were only performed with populations genotyped for this study.