Figure 5

Schematic presentation of the shared haplotype across five dogs from three different breeds. Alignment of the affected haplotype observed in five dogs carrying the cd-affected chromosome. Single nucleotide polymorphisms (SNPs) are represented by letters, and their location is denoted in the header. The minimal shared haplotype is boxed in red (0.5 Mb) and the maximum shared haplotype is marked with the dashed extended box (1.04 Mb). A. AM-derived colony dog affected with cd. B. Affected haplotype observed in a homozygous state in a purebred AM affected with cd and in a heterozygous state in its parent. C. MAS affected with cd. D. Siberian husky carrying the cd-affected chromosome. Only the affected chromosome is presented in the diagram. Distances from the mutation are represented in the bottom scale and are drawn to scale.