Body composition and gene expression QTL mapping in mice reveals imprinting and interaction effects

BMC Genomic Data

Table 3 Statistics of QTL that interact with Myostatin genotype

			Position	Flanking markers^c		am + dm + im^d		am + dm^e		am^g
Chr	Trait^a	Groups	(cM)^b	Left	Right	P-value	%var	P-value	%var	P-value	% var
1	BMI	pQTL	22	rs3696088	rs13472794	7.35E-02	0.70	3.85E-02	0.65	8.48E-03	0.69
1	Gastro	pQTL	24	rs3696088	rs13472794	2.45E-08	3.58	1.77E-08	3.34	1.49E-01	0.20
1	Pec	pQTL	25	rs3696088	rs13472794	3.95E-12	5.06	1.08E-11	4.56	3.52E-03	0.80
2	P/D	tQTL	61	rs13476636	rs3144393	2.66E-04	2.64	1.56E-04	2.43	1.52E-04	2.00
3	Pec	pQTL	43	rs13477174	rs3670634	2.31E-02	0.95	1.02E-02	0.91	8.95E-02	0.29
3	Atp2a2	eQTL	120	rs3724562	CEL-3_159340478	8.87E-03	1.57	7.31E-03	1.34	3.72E-03	1.14
6	Fat	pQTL	27	rs13478727	rs13478839	4.24E-03	1.31	1.36E-03	1.31	2.74E-04	1.31
6	lengthNT	pQTL	69	UT_6_123.37228	rs3688358	1.34E-01	0.55	7.28E-02	0.52	3.65E-02	0.43
8	AI	pQTL	20	rs13479657	rs13479757	1.42E-02	1.04	5.09E-03	1.04	1.14E-03	1.04
8	Fat	pQTL	20	rs13479657	rs13479757	1.15E-02	1.10	4.13E-03	1.09	9.01E-04	1.09
8	Igf2	eQTL	33	rs13479657	rs13479757	6.63E-02	1.10	3.30E-02	1.05	8.20E-01	0.01
14	BMI	pQTL	63	rs3709178	rs13482404	9.57E-02	0.63	4.50E-02	0.62	1.23E-01	0.24
17	Fat	pQTL	15	rs13482893	rs3719497	4.84E-02	0.74	3.38E-02	0.65	1.44E-02	0.64
17	AI	pQTL	28	rs3023442	rs6395919	3.76E-02	0.83	2.68E-02	0.71	7.06E-03	0.71
17	Soleus	pQTL	69	rs6257479	rs3663966	3.77E-02	0.86	1.82E-02	0.81	3.49E-02	0.45
18	AI	pQTL	42	rs3718618	rs13483438	3.92E-02	0.82	2.97E-02	0.69	4.65E-02	0.39
18	Fat	pQTL	42	rs3718618	rs13483438	3.27E-02	0.87	2.78E-02	0.71	4.88E-02	0.39
X	Atp2a2	eQTL	54	rs13484003	rs13484087	1.74E-04	2.69	1.11E-04	2.46	1.96E-03	1.30
X	Egf	eQTL	56	rs13484003	rs13484087	3.34E-02	1.18	1.75E-02	1.10	1.33E-02	0.83

^aTrait abbreviations are the same as in Table 1. P/D: total protein/total DNA. Atp2a2: ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 expression. Igf2: insulin-like growth factor 2 expression. Egf: epidermal growth factor expression.
^bPeak position of QTL detected in Kosambi centimorgans.
^cFlanking markers (left and right) of the QTL peak. See Additional file 1: Table S6 for marker information.
^dam + dm + im tested the overall interaction, which included additive, dominance, and imprinted pQTL by Myostatin genotype interactions. P-value < 0.05 is shown in italics %var: percentage of phenotypic variance accounted for at QTL position.
^eam + dm tested for non-imprinted interactions, which included additive and dominance pQTL by Myostatin genotype interactions. P-value < 0.05 is shown in italics %var: percentage of phenotypic variance accounted for at QTL position.
^fam tested for additive interactions, which included additive pQTL by Myostatin genotype interactions. P-value < 0.05 is shown in italics % var: percentage of phenotypic variance accounted for at QTL position.

ISSN: 2730-6844