Figure 1

Histological comparison of adrenal X-zone morphologies of DDD-A^y, DDD, B6-A^y, and B6 strains clearly indicating the differences between strains and between sexes. (A) Male adrenal cortex: X-zone was absent in the four strains. Localized atrophy of the cortex or irregularly arranged cortex cells was observed in DDD-A^y and DDD males, but not in B6-A^y and B6 males. (B) Female adrenal cortex: X-zone was present in the four strains. Infiltration of fat cells with large fat droplets was observed in the X-zones of strains DDD-A^y and DDD, whereas no marked changes were observed in strains B6-A^y and B6.