Analysis of DNA variations in GSTA and GSTMgene clusters based on the results of genome-wide data from three Russian populations taken as an example

Table 6 Comparisons of the haplotype diversity of GSTM cluster in populations of Tver, Murom, Kursk and HapMap populations (CEU, CHB, JPT, YRI) *

	MUROM	KURSK	СЕU	CHB	JPT	YRI	Number of haploblock	The level of significance
TVER	0,5078	0,5183	0,2862	0,0021	<0,0001	0,4485	I	0,0025
	0,3202	0,8943	0,2160	<0,0001	<0,0001	<0,0001	II	0,0019
	0,9120	0,9206	0,7647	<0,0001	<0,0001	<0,0001	III	0,0025
MUROM		0,6541	0,3994	0,0027	<0,0001	0,5856	I	0,0025
		0,4052	0,1369	<0,0001	<0,0001	<0,0001	II	0,0019
		0,9392	0,5527	<0,0001	<0,0001	<0,0001	III	0,0025
KURSK			0,0811	0,0313	0,0018	0,1701	I	0,0025
			0,0906	<0,0001	<0,0001	<0,0001	II	0,0019
			0,8592	<0,0001	<0,0001	<0,0001	III	0,0025

* Pairwise P-values are presented. The last column contains Bonferroni adjusted P-values calculated for each block. The calculations was performed using the formula P = 0.05/ ([n × a] – 1), where “n” is the number of haplotypes and “a” is the number of populations [16].

ISSN: 2730-6844