TY - JOUR AU - Chen, Chuang AU - Herzig, Carolyn TA AU - Alexander, Leeson J. AU - Keele, John W. AU - McDaneld, Tara G. AU - Telfer, Janice C. AU - Baldwin, Cynthia L. PY - 2012 DA - 2012/10/16 TI - Gene number determination and genetic polymorphism of the gamma delta T cell co-receptor WC1 genes JO - BMC Genetics SP - 86 VL - 13 IS - 1 AB - WC1 co-receptors belong to the scavenger receptor cysteine-rich (SRCR) superfamily and are encoded by a multi-gene family. Expression of particular WC1 genes defines functional subpopulations of WC1+ γδ T cells. We have previously identified partial or complete genomic sequences for thirteen different WC1 genes through annotation of the bovine genome Btau_3.1 build. We also identified two WC1 cDNA sequences from other cattle that did not correspond to sequences in the Btau_3.1 build. Their absence in the Btau_3.1 build may have reflected gaps in the genome assembly or polymorphisms among animals. Since the response of γδ T cells to bacterial challenge is determined by WC1 gene expression, it was critical to understand whether individual cattle or breeds differ in the number of WC1 genes or display polymorphisms. SN - 1471-2156 UR - https://doi.org/10.1186/1471-2156-13-86 DO - 10.1186/1471-2156-13-86 ID - Chen2012 ER -