Table 1 Patient and quality control characteristics by sample type
From: Quantitative criteria for improving performance of buccal DNA for high-throughput genetic analysis
N | All | Buccal | Blood |
|---|---|---|---|
850 | 708 (83%) | 142 (17%) | |
Patient | |||
Age (years ± SD) | 66.7 ± 14.8 | 67.2 ± 14.8 | 64.6 ± 14.9 |
Sex (% male) | 417 (49.1%) | 348 (49.2%) | 69 (48.6%) |
Stroke status (% cases) | 433 (50.9%) | 353 (49.9%) | 80 (56.3%) |
Cigarette smoker (% current) | 163 (19.2%) | 136 (19.2%) | 27 (19.0%) |
Pre-genotyping QC | |||
QC Failure (%)a | 90 (10.6%) | 80 (11.3%) | 10 (7.0%) |
cQC <0.4 | 75 (8.8%) | 69 (9.7%) | 6 (4.2%) |
DM call rate <83% | 65 (7.6%) | 60 (8.5%) | 5 (3.5%) |
Gender mismatch | 24 (2.8%) | 19 (2.7%) | 5 (3.5%) |
cQC rate | 2.08 ± 0.94 | 2.00 ± 0.94 | 2.53 ± 0.82*** |
Among passed samples | 2.33 ± 0.65 | 2.24 ± 0.65 | 2.69 ± 0.55*** |
Among failed samples | 0.05 ± 0.43 | 0.01 ± 0.37 | 0.36 ± 0.71 |
DM call rate | 93.1 ± 7.8% | 92.7 ± 8.3% | 95.1 ± 4.0% *** |
Among passed samples | 95.3 ± 2.8% | 95.1 ± 2.9% | 96.0 ± 1.9% *** |
Among failed samples | 74.7 ± 11.7% | 73.5 ± 11.7% | 83.9 ± 6.9% ** |