TY - JOUR AU - Struchalin, Maksim V. AU - Amin, Najaf AU - Eilers, Paul HC AU - van Duijn, Cornelia M. AU - Aulchenko, Yurii S. PY - 2012 DA - 2012/01/24 TI - An R package "VariABEL" for genome-wide searching of potentially interacting loci by testing genotypic variance heterogeneity JO - BMC Genetics SP - 4 VL - 13 IS - 1 AB - Hundreds of new loci have been discovered by genome-wide association studies of human traits. These studies mostly focused on associations between single locus and a trait. Interactions between genes and between genes and environmental factors are of interest as they can improve our understanding of the genetic background underlying complex traits. Genome-wide testing of complex genetic models is a computationally demanding task. Moreover, testing of such models leads to multiple comparison problems that reduce the probability of new findings. Assuming that the genetic model underlying a complex trait can include hundreds of genes and environmental factors, testing of these models in genome-wide association studies represent substantial difficulties. SN - 1471-2156 UR - https://doi.org/10.1186/1471-2156-13-4 DO - 10.1186/1471-2156-13-4 ID - Struchalin2012 ER -