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Table 2 Suppressors of the caffeine sensitivity of mcm2 AA

From: Mcm2 phosphorylation and the response to replicative stress

Gene

ORF

Function

GO

srs2Δ

YJL092C

DNA repair, helicase

1

mcr1Δ

YKL150W

Oxidative stress response

1

tof1Δ

YNL273W

Subunit of fork pausing complex

1,2,5

rad9Δ

YDR217C

Transmission of checkpoint signal

1,2,4,56

rad2Δ

YGR258C

Nucleotide excision repair

1,4,6

pdr15Δ

YDR406W

Cellular detoxification

1,3

rds2Δ

YPL133C

Transcription factor

1,6,7

yhp1Δ

YDR451C

Transcription factor/cell cycle

2,4,6

mbp1Δ

YDL056W

Transcription factor/cell cycle

2,4,6

ume6Δ

YDR207C

Transcription factor

2,4,5,6

hrd1Δ

YOL013C

Ubiquitin ligase/ER assoc. decay

8

ssm4Δ

YIL030C

Ubiquitin ligase/ER assoc. decay

8

pac10Δ

YGR078C

Protein folding

8

sip18Δ

YMR175W

Osmotic stress

9

rpl8bΔ

YLL045C

Ribosomal protein

9

ett1Δ

YOR051C

Translation termination

9

  1. Genes are grouped by their GO terms as annotated in the Saccharomyces cerevisiae database [37]. Horizontal lines separate different classes. Gene ontology: (1) Response to cell stress/chemical stimuli (2) cell cycle, (3) transport, (4) RNA metabolic process, (5) signalling process/protein modification process, (6) transcription, (7) carbohydrate metabolic process, (8) ER-mediated degradation & protein-folding and (9) other.