Table 4 QTL influencing hearing in CBA-F2 and C57-F2 mice
Line | Trait | Chr | Marker | LRS (LOD) | pValue | Effect |
|---|---|---|---|---|---|---|
C57-F2 | ||||||
32 kHz ABR | 10 | rs13480621 | 280.2 (60.7) | <0.00001 | 57% | |
HFEA | 10 | rs13480621 | 311.6 (67.6) | <0.00001 | 63% | |
7 | D7MIT83 | 10.2 (2.2) | 0.00614 | 2% | ||
PC1 | 10 | rs13480621 | 259.9 (56.4) | <0.00001 | 56% | |
PC2 | 10 | rs13480621 | 25.8 (5.6) | <0.00001 | 8% | |
PC3 | 10 | rs39365220 | 12.0 (2.6) | 0.00250 | 4% | |
5–9 kHz | 10 | rs3089912 | 19.2 (4.2) | 0.00007 | 6% | |
10–14 kHz | 10 | rs13480621 | 20.4 (4.4) | 0.00004 | 6% | |
15–19 kHz | 10 | rs13480621 | 35.3 (7.7) | <0.00001 | 11% | |
20–24 kHz | 10 | rs13480621 | 143.0 (31.0) | <0.00001 | 36% | |
25–29 kHz | 10 | rs13480621 | 202.6 (43.9) | <0.00001 | 47% | |
30–34 kHz | 10 | rs13480621 | 250.1 (54.3) | <0.00001 | 55% | |
35–39 kHz | 10 | rs13480621 | 290.1 (62.9) | <0.00001 | 60% | |
7 | D7MIT83 | 11.4 (2.5) | 0.00336 | 2% | ||
40–44 kHz | 10 | rs13480621 | 176.2 (38.2) | <0.00001 | 43% | |
45–49 kHz | 10 | rs13480621 | 178.1 (38.6) | <0.00001 | 22% | |
50–55 kHz | 10 | rs13480621 | 87.8 (19.0) | <0.00001 | 24% | |
CBA-F2 | ||||||
HFEA | 7 | rs3680765 | 19.7 (4.27) | 0.00005 | 7% | |
9 | rs13480313 | 10.9 (2.4) | 0.00425 | 4% | ||
PC1 | 7 | rs3680765 | 18.5 (4.0) | 0.00010 | 6% | |
PC3 | 7 | rs3719301 | 10.9 (2.4) | 0.00428 | 4% | |
35–39 kHz | 7 | rs3680765 | 22.4 (4.9) | 0.00001 | 7% | |
40–44 kHz | 7 | rs3680765 | 13.4 (2.9) | 0.00122 | 5% | |
9 | rs13480313 | 11.0 (2.4) | 0.00415 | 4% | ||
45–49 kHz | 7 | rs3680765 | 15.1 (3.3) | 0.00053 | 5% | |
50–55 kHz | 7 | rs8255275 | 11.4 (2.5) | 0.00346 | 4% |