Figure 5

Phylogetic representation of amino acid sequence alignments of independent domains. Trees were obtained as described in Methods section at http://www.phylogeny.fr. Numbers close to the nodes represent the support value for each branch. Prior to phylogenetic analyses, cDNA sequences were translated and datasets were partitioned into a group with sequences of catalytic domains (amino acid residues at positions 1-214 of BnMP-III) or disintegrin/disintegrin-like domains (amino acid residues at positions 215-307 of BnMP-III). (*) indicates sequences of SVMPs class P-II; (#) indicates non-hemorrhagic class P-III SVMPs. The description, accession numbers and SVMP classification for other species sequences are shown in Table 2.