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Figure 1 | BMC Genetics

Figure 1

From: A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene

Figure 1

Phenotypes of the swh/swh rat as hypohidrotic ectodermal dysplasia (HED). A, Sections of the dorsal skin (left) and hair (right). Incomplete hair follicles are evident in swh/swh rat. Scale bar, 0.5 mm. The WTC rat has four hair types; auchene, zigzag, awl and guard, while the swh/swh rat have only the abnormal awl hair. B, Whole mount stained mammary glands; 6-week-old (left), 8-week-old (center), and pregnant day 9 (right). Mammary gland branching is poor in swh/swh rat. Scale bar, 1 mm. C, Sweat test results (left) and section of the footpads. Sweat, detected as dark spots, is not seen in swh/swh rat. Sweat glands (arrowhead) are present in WTC rat and absent in swh/swh rat. Scale bar, 100 μm. D, Sections of the eyelid. The meibomian glands (arrowhead) are present in WTC rat and absent in swh/swh rat. Scale bar, 100 μm. E, An entire view (left) and a section of the preputial gland (right). The preputial gland is atrophied in male swh/swh rat. Acinous glands (arrowhead) are present in WTC rat and absent in swh/swh rat. Scale bar, 100 μm. F, Section of the tongue. Both mucous (open arrowhead) and serous (filled arrowhead) glands are present in WTC rat and neither is seen in swh/swh rat. Scale bar, 0.5 mm. G, Buccal views of lower molars (left), tip of tail (center), and posterior auricular region (right). Cusp number is reduced in the first molar (arrow head) in swh/swh rat. Some swh/swh rats show the kink tail. The bald patch behind the ear was not evident in the swh/swh rat.

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