Meta-analysis of haplotype-association studies: comparison of methods and empirical evaluation of the literature

Bagos, Pantelis G

doi:10.1186/1471-2156-12-8

BMC Genomic Data

Table 2 List of the 43 meta-analyses that were used in the empirical evaluation

From: Meta-analysis of haplotype-association studies: comparison of methods and empirical evaluation of the literature

ID	Reference	Gene/Locus	Disease/Outcome	SNPs in haplotype	Number of studies	Sample Size	Method of analysis	Data availability	Collaborative analysis	Significant results
1	[109]	DRD3	Schizophrenia	4	5	7551	1 vs. others	No	No	No
2	[98]	ITGAV	Rheumatoid Arthritis	3	3	6851	N/A	Yes	Yes	Yes
3	[110]	IL1A/IL1B/IL1RN	Osteoarthritis	7	4	2908	1 vs. others	No	Yes	Yes
4	[111]	FRZB	Osteoarthritis	2	10	12380	1 vs. others	No	Yes	No
5	[99]	CX3CR1	CAD	2	6	2912	1 vs. others	Yes	No	Yes
6	[112]	ALOX5AP	Stroke	4	5	5765	1 vs. others	No	No	No
7	[112]	ALOX5AP	Stroke	4	3	3004	1 vs. others	No	No	No
8	[113]	GNAS	Malaria	3	7	8154	1 vs. others	No	Yes	Yes
9	[113]	GNAS	Malaria	7	6	7632	1 vs. others	No	Yes	Yes
10	[114]	PDLIM5	Bipolar Disorder	2	3	1208	1 vs. others	No	No	No
11	[115]	PDE4D	Stroke	2	4	4961	1 vs. others	No	No	Yes
12	[116]	TGFB1	Renal Transplantation	2	4	438	pooled	No	No	Yes
13	[116]	IL10	Renal Transplantation	3	4	348	pooled	No	No	No
14	[117]	9p21.3	CAD	4	5	7838	1 vs. others	No	Yes	Yes
15	[118]	HLA	SLE	2	3	527	1 vs. others	No	No	Yes
16	[94]	CTLA4	Graves Disease	2	10	2564	1 vs. others	Yes	Yes	Yes
17	[94]	CTLA4	Hashimoto Thyroiditis	2	5	1210	1 vs. others	Yes	Yes	Yes
18	[119]	ENPP1	T2DM	3	3	8676	1 vs. others	No	No	No
19	[77]	MTHFR	ALL	2	4	894	Log-linear model	No	No	Yes
20	[97]	CAPN10	T2DM	3	11	5862	1 vs. others	Yes	Yes	Yes
21	[93]	ADAM33	Asthma	5	3	1899	pooled	Yes	No	No
22	[120]	NRG1	Schizophrenia	6	11	8722	1 vs. others	No	No	Yes
23	[121]	RGS4	Schizophrenia	4	8	7243	1 vs. others	No	Yes	No
24	[122]	ADRB2	Asthma	2	3	2060	N/A	No	No	Yes
25	[123]	ESR1	Fractures	3	8	14622	1 vs. others	No	Yes	Yes
26	[78]	VDR	Osteoporosis	3	4	2335	Log-linear model	Yes	No	Yes
27	[95]	ACE	Alzheimer's Disease	3	4	1619	pooled	Yes	Yes	Yes
28	[124]	IGF-I	IGF-I levels	3	3	1929	1 vs. others	No	Yes	Yes
29	[125]	TF	Stroke	2	2	818	N/A	No	Yes	No
30	[92]	FcgammaR	Celliac Disease	2	2	1057	N/A	Yes	Yes	No
31	[69]	VDR	Fractures	3	9	23309	Logistic regression	No	Yes	No
32	[96]	G72/G30	Schizophrenia	2	2	1541	N/A	Yes	Yes	Yes
33	[68]	VEGF	ALS	3	4	1912	Logistic regression	Yes	Yes	Yes
34	[126]	BANK1	Rheumatoid Arthritis	3	4	4445	1 vs. others	No	Yes	Yes
35	[67]	CYP19A1	Endometrial Cancer	2	10	13283	Logistic regression	No	Yes	Yes
36	[127]	CRP	T2DM	3	3	11876	N/A	No	No	Yes
37	[66]	8q24	Colorectal Adenoma	4	3	5385	Logistic regression	No	Yes	Yes
38	[128]	CYP1A1	Lung Cancer	2	13	2151	Pooled	No	Yes	Yes
39	[91]	TNFA	Prostate Cancer	5	2	4881	Pooled	Yes	Yes	No
40	[90]	PTGS2	Prostate Cancer	4	2	4881	Pooled	Yes	Yes	No
41	[129]	AR	Endometrial Cancer	5	2	1424	Pooled	No	Yes	No
42	[130]	MGMT	Head and Neck Cancer	2	3	1347	Pooled	No	Yes	No
43	[131]	SNCA	Parkinson Disease	2	11	5344	1 vs. other	No	Yes	Yes

We list the reference, the gene name, the disease, the number of SNPs included in the haplotypes, the number of studies, the total sample size, the method of analysis (N/A: not available), the availability of data, whether the data was collected in a collaborative setting and whether the study reported significant results.

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ISSN: 2730-6844

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