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Table 2 Distribution of IL12B 3' UTR genotypes in children with P. falciparum malaria

From: Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria

IL12B 3' UTR Genotypes

Non-SMA

SMA

P a

No. of participants, n

304

240

 

AA

132 (43.4)

82 (34.2)

 

AC

123 (40.5)

104 (43.3)

0.048

CC

49 (16.1)

54 (22.5)

 
 

P(A) = 0.64

P(A) = 0.56

 
  1. Data are presented as proportion of individuals [n (%)] within non-SMA and SMA groups. Children with P. falciparum malaria (n = 544) were categorized according to SMA status based on age- and geographically-appropriate Hb concentrations [i.e., Hb<6.0 g/dL, with any density parasitaemia) [4]] and non-SMA (Hb≥6.0 g/dL, with any density parasitaemia). aStatistical significance determined by Chi-square analysis. The overall distribution of genotypes between the non-SMA and SMA groups was statistically significant (χ2 test, P = 0.048).