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Table 2 Distribution of IL12B 3' UTR genotypes in children with P. falciparum malaria

From: Polymorphic variability in the 3' untranslated region (UTR) of IL12B is associated with susceptibility to severe anaemia in Kenyan children with acute Plasmodium falciparum malaria

IL12B 3' UTR Genotypes Non-SMA SMA P a
No. of participants, n 304 240  
AA 132 (43.4) 82 (34.2)  
AC 123 (40.5) 104 (43.3) 0.048
CC 49 (16.1) 54 (22.5)  
  P(A) = 0.64 P(A) = 0.56  
  1. Data are presented as proportion of individuals [n (%)] within non-SMA and SMA groups. Children with P. falciparum malaria (n = 544) were categorized according to SMA status based on age- and geographically-appropriate Hb concentrations [i.e., Hb<6.0 g/dL, with any density parasitaemia) [4]] and non-SMA (Hb≥6.0 g/dL, with any density parasitaemia). aStatistical significance determined by Chi-square analysis. The overall distribution of genotypes between the non-SMA and SMA groups was statistically significant (χ2 test, P = 0.048).