TY - JOUR AU - Mathias, Rasika A. AU - Sergeant, Susan AU - Ruczinski, Ingo AU - Torgerson, Dara G. AU - Hugenschmidt, Christina E. AU - Kubala, Meghan AU - Vaidya, Dhananjay AU - Suktitipat, Bhoom AU - Ziegler, Julie T. AU - Ivester, Priscilla AU - Case, Douglas AU - Yanek, Lisa R. AU - Freedman, Barry I. AU - Rudock, Megan E. AU - Barnes, Kathleen C. AU - Langefeld, Carl D. AU - Becker, Lewis C. AU - Bowden, Donald W. AU - Becker, Diane M. AU - Chilton, Floyd H. PY - 2011 DA - 2011/05/20 TI - The impact of FADS genetic variants on ω6 polyunsaturated fatty acid metabolism in African Americans JO - BMC Genetics SP - 50 VL - 12 IS - 1 AB - Arachidonic acid (AA) is a long-chain omega-6 polyunsaturated fatty acid (PUFA) synthesized from the precursor dihomo-gamma-linolenic acid (DGLA) that plays a vital role in immunity and inflammation. Variants in the Fatty Acid Desaturase (FADS) family of genes on chromosome 11q have been shown to play a role in PUFA metabolism in populations of European and Asian ancestry; no work has been done in populations of African ancestry to date. SN - 1471-2156 UR - https://doi.org/10.1186/1471-2156-12-50 DO - 10.1186/1471-2156-12-50 ID - Mathias2011 ER -