Table 3 Genotype associations
From: MCP1 haplotypes associated with protection from pulmonary tuberculosis
MCP1 | GT | cases n (frequency) | controls n (frequency) | OR | CI | Pnom | Pcorr | ORtrend | CI | Pnom | Pcorr |
|---|---|---|---|---|---|---|---|---|---|---|---|
-97569 | CC | 278 (0.14) | 328 (0.14) | 1 | 1.00 | [0.92-1.10] | 0.99 | ||||
CG | 941 (0.47) | 1089 (0.47) | 1.02 | [0.85-1.23] | 0.81 | ||||||
GG | 765 (0.39) | 900 (0.39) | 1.01 | [0.84-1.22] | 0.92 | ||||||
-38600 | CC | 629 (0.32) | 666 (0.29) | 1 | 0.91 | [0.83-0.99] | 0.03 | ||||
CT | 970 (0.49) | 1131 (0.50) | 0.91 | [0.79-1.05] | 0.20 | ||||||
TT | 380 (0.19) | 488 (0.21) | 0.83 | [0.70-0.99] | 0.03 | ||||||
-2581* | AA | 1355 (0.69) | 1472 (0.64) | 1 | 0.81 | [0.73-0.91] | 0.0003 | 0.0018 | |||
AG | 546 (0.28) | 748 (0.32) | 0.79 | [0.69-0.90] | 0.001 | 0.006 | |||||
GG | 63 (0.03) | 92 (0.04) | 0.73 | [0.53-1.02] | 0.064 | ||||||
-1727 | TT | 1708 (0.94) | 1994 (0.93) | 1 | 0.88 | [0.69-1.13] | 0.32 | ||||
AT | 109 (0.06) | 145 (0.07) | 0.87 | [0.67-1.12] | 0.27 | ||||||
AA | 2 (<0.01) | 2 (<0.01) | 1.34 | [0.19-9.58] | 0.77 | ||||||
-362* | GG | 672 (0.34) | 654 (0.28) | 1 | 0.83 | [0.76-0.91] | 0.000026 | 0.00021 | |||
CG | 922 (0.47) | 1133 (0.49) | 0.80 | [0.69-0.92] | 0.001 | 0.008 | |||||
GG | 374 (0.19) | 514 (0.22) | 0.70 | [0.59-0.83] | 0.00005 | 0.0004 | |||||
Int1:96 | CC | 145 (0.09) | 152 (0.07) | 1 | 0.87 | [0.78-0.96] | 0.006 | ||||
CG | 677 (0.40) | 788 (0.37) | 0.90 | [0.70-1.16] | 0.4 | ||||||
GG | 862 (0.51) | 1170 (0.55) | 0.77 | [0.60-0.98] | 0.037 | ||||||
Int1:554 | WW | 743 (0.37) | 734 (0.31) | 1 | 0.84 | [0.77-0.92] | 0.00014 | 0.00098 | |||
-567 | DW | 946 (0.47) | 1178 (0.50) | 0.80 | [0.70-0.91] | 0.0009 | 0.0063 | ||||
DD | 320 (0.16) | 425 (0.18) | 0.73 | [0.60-0.98] | 0.0006 | 0.0042 | |||||
+1542 | CC | 1358 (0.68) | 1494 (0.64) | 1 | 0.86 | [0.77-0.96] | 0.009 | ||||
CT | 575 (0.29) | 757 (0.32) | 0.84 | [0.73-0.95] | 0.007 | ||||||
TT | 68 (0.03) | 88 (0.04) | 0.84 | [0.60-1.16] | 0.29 | ||||||
+2413 | GG | 813 (0.86) | 1232 (0.86) | 1 | 1.02 | [0.92-1.29] | 0.819 | ||||
GT | 124 (0.13) | 188 (0.13) | 0.99 | [0.78-1.28] | 0.99 | ||||||
TT | 5 (<0.01) | 5 (<0.01) | 1.54 | [0.44-5-47] | 0.5 | ||||||
+2580 | AA | 26 (0.01) | 21 (<0.01) | 1 | 0.97 | [0.84-1.12] | 0.711 | ||||
AT | 345 (0.17) | 412 (0.18) | 0.69 | [0.38-1.25] | 0.22 | ||||||
TT | 1623 (0.81) | 1886 (0.81 | 0.70 | [0.39-1.25] | 0.23 |