Figure 2

The Expected Test Statistics E( T ) under the Alternative Hypothesis as a Function of Minor Allele Frequencies (MAFs, ρ ) and Odds Ratios (ORs, exp ( β )) given a Fixed Sample Size n = 2000. The expected test statistics under the alternative hypothesis were estimated using Equation (1), where we used σ = 4.6, n = 2000, and assumed an additive underlying genetic model. We observed that, when MAF = 0.4 and OR = 1.5, E(T) = 4.1733; when MAF = 0.1 and OR = 1.8, E(T) = 2.6813.