DNA sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in Irish Holstein-Friesian cattle

Table 1 The eight candidate bovine imprinted genes analysed in this study

Gene	Ensembl gene ID	BTA¹	Gene function²	Imprinting status in cattle	Additional species in which gene is imprinted/Preferentially-expressed allele³
CALCR	ENSBTAG00000017458	4	Involved in regulating calcium homeostasis; involved in osteoclast-mediated bone resorption	No data available	Human; Mouse/ Maternal expression in both species
GRB10	ENSBTAG00000017086	4	Involved in signal transduction; interacts with insulin receptors and insulin-like growth factor receptors	Tested but unconfirmed⁴	Human; Mouse; Sheep/ Isoform-dependent maternal and paternal expression
ZNF215	ENSBTAG00000003638	15	Putative role in transcriptional regulation	No data available	Human/ Maternal expression but biallelic expression has been reported in some tissues
PEG3	ENSBTAG00000023338	18	Role in cellular apoptosis	Imprinted, paternal expression⁵	Human; Mouse; Sheep/ Paternal expression in all species
ZIM2	ENSBTAG00000011664	18	Putative role in transcriptional regulation	Biallelic expression⁶	Human; Mouse/ Paternal expression in humans. Tissue-specific maternal and biallelic expression has been reported in mouse
RASGRF1	ENSBTAG00000019940	21	Signal transduction and cellular proliferation	No data available	Mouse/ Paternal expression
PHLDA2	ENSBTAG00000031194	29	Tumour suppressor gene	No data available	Human; Mouse; Pig/ Maternal expression
TSPAN32	ENSBTAG00000002702	29	Possible tumour-suppressor functions	No data available	Mouse/ Developmental-stage specific maternal expression

Information regarding the expressed allele for all eight genes is based on the patterns of imprinting in mouse and human and, where possible, cattle, sheep and pigs. The chromosomal location of each gene was obtained from the ENSEMBL database (http://www.ensembl.org) and are based on Build 4.0, Ensembl release 59, of the B. taurus genome sequence (August 2010). The ENSEMBL database gene identity (ID) for each gene is given.
¹ B. taurus chromosome number
² Data taken from the GeneCards Version 3 database [64]; [http://www.genecards.org]
³ Data taken from the Catalogue of Parent-of-Origin Effects database [16] and the Geneimprint database [14]
⁴ Tveden-Nyborg et al. [34]
⁵ Khatib et al. [35]
⁶ Kim et al. [32]; Kim et al. [33]

ISSN: 2730-6844