Robust tests for matched case-control genetic association studies

BMC Genomic Data

Table 4 Empirical powers of Z_MTT(0), Z_MTT(0.5), Z_MTT(1), Z_SGMS, Z_SGME, Z_MAX3 and $Z_{χ^{2}}$ with 2 df based on 10,000 replicates.

Scenario	Model	Z_MTT(0)	Z_MTT(0.5)	Z_MTT(1)	Z _SGMS	Z _SGME	Z _MAX3	$Z_{χ^{2}}$	ρ*
A	REC	0.8059	0.5590	0.1369	0.6981	0.6760	0.7340	0.7154	0.3267
	ADD	0.4890	0.7998	0.7126	0.7594	0.7896	0.7629	0.7188	0.7623
	DOM	0.1237	0.6818	0.8040	0.7142	0.7155	0.7300	0.7158	0.2639
B	REC	0.8073	0.5367	0.1356	0.6725	0.6497	0.7229	0.7147	0.3423
	ADD	0.4637	0.7977	0.7258	0.7646	0.7908	0.7502	0.7140	0.7445
	DOM	0.1287	0.7011	0.8054	0.7168	0.7259	0.7383	0.7199	0.2756
C	REC	0.8057	0.5503	0.1330	0.6970	0.6691	0.7244	0.7153	0.3038
	ADD	0.4896	0.8052	0.7139	0.7654	0.7952	0.7648	0.7094	0.7295
	DOM	0.1193	0.6877	0.8062	0.7153	0.7210	0.7445	0.7112	0.2710
D	REC	0.7978	0.5235	0.1400	0.6655	0.6433	0.7177	0.7144	0.3124
	ADD	0.4639	0.8045	0.7308	0.7654	0.7934	0.7499	0.7090	0.7037
	DOM	0.1204	0.7024	0.8071	0.7144	0.7225	0.7250	0.7033	0.2792
E	REC	0.7974	0.5276	0.1453	0.7166	0.6782	0.7288	0.7218	0.3492
	ADD	0.4667	0.8014	0.7294	0.7554	0.7884	0.7517	0.7131	0.7396
	DOM	0.1261	0.6989	0.8027	0.7135	0.7234	0.7161	0.7077	0.2795
F	REC	0.8056	0.5547	0.1535	0.6991	0.6742	0.7317	0.7173	0.3561
	ADD	0.5014	0.8068	0.7195	0.7650	0.7955	0.7524	0.7112	0.7661
	DOM	0.1389	0.6933	0.8003	0.7167	0.7231	0.7291	0.7141	0.2887
G	REC	0.8045	0.5241	0.1499	0.7233	0.6786	0.7316	0.7082	0.3172
	ADD	0.4562	0.8020	0.7313	0.7522	0.7883	0.7560	0.7068	0.6970
	DOM	0.1247	0.7091	0.8004	0.7167	0.7297	0.7468	0.7099	0.2825
H	REC	0.7967	0.5481	0.1467	0.6950	0.6651	0.7203	0.7136	0.3279
	ADD	0.4885	0.8017	0.7154	0.7610	0.7911	0.7529	0.7009	0.7272
	DOM	0.1254	0.6944	0.8055	0.7183	0.7248	0.7366	0.7091	0.2945

The settings are the same as those in Table 2 except that the GRRs are determined so that the optimal MTT has the maximum power of about 80%. The significance level is 0.05. ρ* is the minimum correlation of the optimal tests.

ISSN: 2730-6844