Skip to main content

Table 2 Inflation before and after principal component correction

From: Comparison of multimarker logistic regression models, with application to a genomewide scan of schizophrenia

Model λ ^ without PC adjustment λ ^ with PC adjustment
Single-SNP tests* 1.070 1.077
Main-effects 1.101 1.059
Main+adj 1.092 1.052
Haplotype 1.064 1.037
  1. Comparison of inflation in median test statistics ( λ ^ ) for each model with and without principal components. *Single-SNP tests without PC adjustment were Cochran-Armitage trend statistics which are not able to incorporate PC adjustment. The single-SNP statistics with PC adjustment are the 1 d.f. logistic regression.
Back to article page

BMC Genomic Data

ISSN: 2730-6844

Contact us