Association of HPA axis-related genetic variation with stress reactivity and aggressive behaviour in pigs

BMC Genomic Data

Table 1 RYR1 and candidate gene DNA marker frequencies in different lines

Gene	Position^2,3	Allele	SYN⁴	PiF1a	LR	LW	Pi	WB	MK
SNP designation ¹			n = 427	n = 208	n = 24	n = 26	n = 25	n = 22	n = 17
RYR1 c.1843C>T	coding (p.R615C)^a	C	0.83	0.75	NA	NA	0.58	NA	NA
*CRH* g.233C>T	promoter^b	C	0.59	0.54	0.67	0.52	0.47	0.48	1.00
*CRHR1* *c.866_867insA**	3'UTR^c	Del	0.54	0.42	0.71	0.58	0.50	1.00	0.32
*CRHBP* c.51G>A	coding (p.M17I)^c	G	0.92	0.92	0.92	0.77	0.92	1.00	0.84
*POMC* c.293_298del	coding (p.G96_G97del)^c	Ins	0.98	0.95	0.94	0.96	1.00	1.00	0.03
*MC2R* c.306T>G	coding (silent)^d	T	0.11	0.17	0.44	0.02	0.16	0.00	0.03
*NR3C1* *c.2122A>G**	3'UTR^c	A	0.49	0.50	0.48	0.21	0.42	0.05	1.00
*AVP* c.207A>G	coding (silent)^c	A	0.66	0.62	0.65	0.58	0.80	0.66	0.97
*AVPR1B* c.1084A>G	coding (p.S362G)^c	A	0.89	0.83	0.65	0.90	0.90	1.00	0.24
*UCN* g.1329T>C	promoter^c	T	0.88	0.84	0.94	0.73	0.94	1.00	0.59
*CRHR2* *c.13T>C**	3' UTR^c	T	0.49	0.59	0.54	0.73	0.38	0.95	0.81

¹SNP designation according to the HGVS nomenclature. Reference sequence is given in Additional File 1, Table S1-S4
²Gene region where the analyzed polymorphism is located. For polymorphisms in the coding region the effect on protein sequence is given in parenthesis.
³Reference: ^a[22], ^b[29], ^cdbSNP submitter accession numbers listed in Additional File 1, Table S1-S4, ^d[30]
⁴Lines: SYN-synthetic, PiF1a-Pietrain × (German Large White × German Landrace), LR-German Landrace, LW-German Large White, Pi-Pietrain, WB-Wild Boar, MK-Muong Khuong
Underline: the genotype distribution departures from Hardy-Weinberg equilibrium at p < 0.05
Italic underline: the genotype distribution departures from Hardy-Weinberg equilibrium at p < 0.01
NA-not analyzed

ISSN: 2730-6844