Figure 3

Calcineurin activity in the sensory neurons is required for maintenance of swimming. A) Distribution of quiescent bouts for Wild type (same as Figure 1A), cnb-1(jh103), tax-6(db60), tax-6(db60)(mr), tax-6(db60)(s+i) and tax-6(db60)(s+i-). tax- 6(db60)(mr) (n = 48 worms), tax-6(db60)(s+i+) (n = 35 worms) and tax-6(db60)(s+i-) (n = 37 worms) refers to a wild type tax-6 cDNA expressed in muscles (under myo-3 promoter), sensory and interneurons (under unc-14p promoter) and sensory neurons (under 1.1 Kb fragment of tax-6 promoter) respectively in a tax-6(db60) mutant background. Each point represents a single quiescent bout. Medians are shown as horizontal black bars (for means and errors see Table 1). *** indicates significantly different from wild type p < 0.0001 as determined by Kruskal-Wallis test follwed by Dunn's multiple comparison. B) PKG and calcineurin genetically interact to regulate swim quiescence pattern. Fraction of worms in quiescence versus time for wild type (same as Figure 1B), egl- 4(ks60) (same as Figure 1B), cnb-1(jh103) (n = 24), egl-4(ks60);cnb-1(jh103) (n = 24) worms.