Incorporation of covariates in simultaneous localization of two linked loci using affected relative pairs

BMC Genomic Data

Table 1 Simultaneous two-locus search incorporating quantitative traits with QTLs at τ₁(X_QTL1) or τ₂(X_QTL2)

	Disease Loci (cM)				Estimate of C								95% coverage probability (%)				y_l: covariate for modeling C_l, l= 1, 2
	Parametric		Nonparametric		Parametric				Nonparametric				Parametric		Nonparametric
	τ ₁	τ ₂	τ ₁	τ ₂	ASP		AGP		ASP		AGP		τ ₁	τ ₂	τ ₁	τ ₂
					C₁₁	C₂₁	C₁₄	C₂₄	C₁₁	C₂₁	C₁₄	C₂₄
Bias	0.1	-0.1	-0.008	1.1	0.04	0.03	-0.05	0.01	-0.02	-0.05	-0.04	0.02	95	95	93	91	y₁ = X_QTL1
Sample variance	4.0	4.0	5.4	6.2	0.003	0.003	0.001	0.001	0.002	0.002	0.001	0.001					y₂ = X_QTL1
Mean variance	4.0	4.0	4.8	5.7
$\overset{\land}{β_{1}}$					0.26	-0.25	0.16	-0.08
p-value					0.03	0.05	0.50	0.81
Bias	0.2	-0.05	-1.1	-0.01	0.04	0.03	-0.05	0.02	-0.04	-0.02	-0.04	0.03	94	95	91	93	Y₁ = X_QTL2
Sample variance	4.9	4.2	6.7	5.0	0.003	0.003	0.001	0.001	0.002	0.002	0.001	0.001					y₂ = X_QTL2
Mean variance	4.1	3.8	5.9	4.6
$\overset{\land}{β_{1}}$					-0.25	0.26	-0.09	0.16
p-value					0.05	0.03	0.79	0.53
Bias	0.1	-0.1	-0.5	0.5	0.04	0.03	-0.05	0.02	-0.02	-0.02	-0.04	0.03	94	94	91	91	y₁ = X_QTL1
Sample variance	4.5	4.5	5.7	5.4	0.003	0.003	0.001	0.001	0.002	0.002	0.001	0.001					y₂ = X_QTL2
Mean variance	3.9	3.8	4.8	4.6
$\overset{\land}{β_{1}}$					0.26	0.26	0.16	0.16
p-value					0.03	0.03	0.50	0.53
Bias	0.2	-0.1	-0.6	0.6	0.04	0.04	-0.05	0.02	-0.04	-0.05	-0.04	0.02	94	94	91	91	y₁ = X_QTL2
Sample variance	5.5	5.6	7.6	6.9	0.003	0.003	0.001	0.001	0.002	0.002	0.001	0.001					y₂ = X_QTL1
Mean variance	4.4	4.2	5.9	5.7
$\overset{\land}{β_{1}}$					-0.25	-0.25	-0.09	-0.09
p-value					0.05	0.05	0.79	0.81

ISSN: 2730-6844