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Figure 1 | BMC Genetics

Figure 1

From: Incorporation of covariates in simultaneous localization of two linked loci using affected relative pairs

Figure 1

Relative efficiency (RE) between two approaches in estimating the disease locus under three genetic models (a), (b) and (c). The dotted lines are the RE for comparisons between two types of affected relative pairs in the non-parametric approach. The solid lines are the RE for comparisons between two types of affected relative pairs in the parametric approach. ASP, AGG and COM stand for affected sib pairs, affected grandparent-grandchild, and combined affected sib pairs and grandparent-grandchild pairs, respectively. ASP_wo stands for using ASP without incorporating a covariate. The circle, pund, v and x signs refer to the relationship between the covariate's QTL and the disease locus, including (i) pleiotropy, (ii) co-incident, (iii) unlinked, and (iv) a covariate of age at onset.

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